Diastolic recoil method and device for treatment of cardiac pathologies
Inventors
Criscione, John C. • Biswas, Saurabh • Moreno, Michael R. • Harrison, Lewis D. • Robbins, Dennis I.
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-9642957-B2
Publication Date
2017-05-09
Expiration Date
Abstract
The present invention provides methods and direct cardiac contact device to improve the diastole phase and the systolic phase of a heart and includes a biocompatible film pneumatic locked to the heart to aid in heart compression and relaxation.
Core Innovation
The invention relates to improving diastolic recoil of a heart using a direct cardiac contact compression and diastolic recoil device. A biocompatible inner film is adapted to fit about the heart and maintains constant contact with the heart to form a pneumatic lock, so the biocompatible inner film moves in conjunction with the heart. An interlaced framework is in continuous contact with the biocompatible inner film throughout the cardiac cycle and applies a force during diastole to aid in diastolic recoil.
The device includes an outer film in contact with the biocompatible inner film, one or more fluid chambers formed between the biocompatible inner film and the outer film, and a fluid connection in fluid communication with the one or more fluid chambers. The pneumatic lock between the heart and the biocompatible inner film is formed so the biocompatible inner film moves with the heart, and the one or more fluid chambers are pressurized to expand the biocompatible inner film and selectively compress the heart.
During recoil, the one or more fluid chambers are depressurized to contract the biocompatible inner film and move the biocompatible inner film away from the heart. The pneumatically locked biocompatible inner film pulls the heart open to aid in filling of the heart by using diastolic recoil to improve diastolic function, including treatment of cardiac dysfunction in diastolic, systolic, or combined forms. The description further specifies a biphasic/dynamic support mode using a controllable phase transition point associated with a target end-diastolic volume (TEDV) to switch between a filling enhancement phase and a filling impediment phase.
Claims Coverage
The independent claim describes a method to improve diastolic recoil by implanting a direct cardiac contact compression and diastolic recoil device with a pneumatic lock and pressurize/depressurize control across diastole and recoil. The independent claim contains five main inventive areas: pneumatic lock with a biocompatible inner film, a continuous-contact interlaced framework applying diastolic force, fluid chambers with a fluid connection for selective pressurization, synchronized expansion for systolic compression, and depressurization-based recoil that pulls the heart open to aid filling.
Pneumatic lock with biocompatible inner film moved with the heart
Forming a pneumatic lock between the heart and the biocompatible inner film so that the biocompatible inner film moves in conjunction with the heart, wherein the biocompatible inner film is adapted for constant contact with the heart.
Interlaced framework applying force during diastole
Providing an interlaced framework wherein at least a portion of the interlaced framework is in continuous contact with the biocompatible inner film throughout the cardiac cycle, wherein the interlaced framework applies a force during diastole to aid in diastolic recoil.
Fluid chambers and fluid connection for selective compression
Using one or more fluid chambers formed between the biocompatible inner film and the outer film, and a fluid connection in fluid communication with the one or more fluid chambers.
Pressurizing to expand the inner film and selectively compress the heart
Pressurizing the one or more fluid chambers to expand the biocompatible inner film and selectively compress the heart.
Depressurizing during recoil to contract the inner film and pull the heart open
Depressurizing the one or more fluid chambers during recoil to contract the biocompatible inner film and move the biocompatible inner film away from the heart, wherein the pneumatically locked biocompatible inner film pulls the heart open to aid in filling of the heart.
Overall, the independent claim covers a pneumatic-lock mechanism that maintains constant contact between a biocompatible inner film and the heart, uses fluid-chamber pressurization to selectively compress the heart, and uses depressurization during recoil to contract the inner film and pull the heart open to aid in filling, with an interlaced framework applying force during diastole to aid diastolic recoil.
Stated Advantages
Aid in filling of the heart using pneumatically locked biocompatible inner film pulling the heart open.
Improve diastolic recoil of a heart.
Treat cardiac dysfunction, including diastolic, systolic, or combined forms.
Reduction of dyskinesis and hypokinesis.
Proactive remodeling and restorative rehabilitation.
Reduced thrombosis and infection risk due to no blood contact.
Reduced pericardial adhesions via a multi-layer barrier.
Avoid inverted curvature to improve strain and kinematics.
Support a filling enhancement phase and a filling impediment phase by switching based on a controllable phase transition point associated with TEDV.
Documented Applications
Minimally invasive implantation for treating cardiac dysfunction by improving diastolic recoil and aiding filling of the heart.
Use as an extra-cardiac diastolic recoil system with direct cardiac contact compression for diastolic, systolic, or combined cardiac dysfunction.
Compatibility with cardiac stem cell therapies, including providing a more physiological mechanical strain environment to support cardiomyocyte differentiation [procedural detail omitted for safety].
Use with optional electrical pacing/defibrillation leads as supported by the document.
Interested in licensing this patent?