Blood pressure reduction with dietary supplements
Inventors
Sparks, William S. • De Luca, Daryl L. • De Luca, Denis R. • Houston, Mark
Assignees
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Publication Number
US-9642885-B2
Publication Date
2017-05-09
Expiration Date
Abstract
A daily dose of 6,000 mg of taurine, 1,000 mg of vitamin C, 150 mg of grape seed extract, 100 mg of vitamin B6, 2 mg of biotin, 2,000 IU of vitamin D3, and 87 mg of magnesium is shown to reduce blood pressure in hypertensive individuals by more than 10 mm Hg.
Core Innovation
The patent discloses orally administered dietary supplement compositions and methods for treating high blood pressure, including hypertension and pre-hypertension, in a human in need thereof. The compositions consist essentially of taurine, vitamin C as magnesium ascorbate, grape seed extract, pyridoxine hydrochloride, biotin, and cholecalciferol, administered as an oral dietary supplement composition with specified daily intake ranges.
A key aspect is the defined combination of taurine and magnesium ascorbate together with grape seed extract, pyridoxine hydrochloride, biotin, and cholecalciferol. The document describes a therapeutic approach with component-specific daily ranges and includes embodiments such as a daily single-dose mixed powder.
The patent also reports a placebo-controlled study in hypertensive patients using the disclosed mixed powder composition. The reported outcomes include reductions in systolic blood pressure and diastolic blood pressure compared to placebo after weeks of administration.
Claims Coverage
The patent provides two independent method claims directed to treating high blood pressure/hypertension. Across these independent claims, inventive coverage is anchored by administering the specified ingredient set and, in one claim, prescribing daily dosage ranges for multiple components.
Dosage-ranged taurine and magnesium ascorbate with adjunct polyvitamins and grape seed extract for treating high blood pressure
Administer to a human in need thereof taurine, magnesium ascorbate, grape seed extract, pyridoxine hydrochloride, biotin, and cholecalciferol with daily ranges specified for each component.
Treating hypertension with therapeutically effective amounts of grape seed extract, magnesium ascorbate, cholecalciferol, biotin, taurine, and pyridoxine hydrochloride
Administer therapeutically effective amounts of the ingredient combination to a human in need thereof as a method of treating hypertension.
Overall, the independent claims cover treating high blood pressure/hypertension by administering a defined ingredient combination of taurine, magnesium ascorbate, grape seed extract, pyridoxine hydrochloride, biotin, and cholecalciferol, with one independent claim specifying per-ingredient daily dosage ranges.
Stated Advantages
Reductions in systolic blood pressure versus placebo were reported in the disclosed study after weeks of administration.
Reductions in diastolic blood pressure versus placebo were reported in the disclosed study after weeks of administration.
Documented Applications
Treating high blood pressure in a human in need thereof, including hypertension and pre-hypertension, using an orally administered dietary supplement composition containing taurine, magnesium ascorbate, grape seed extract, pyridoxine hydrochloride, biotin, and cholecalciferol within specified daily ranges.
Treating hypertension in a human in need thereof by administering therapeutically effective amounts of grape seed extract, magnesium ascorbate, cholecalciferol, biotin, taurine, and pyridoxine hydrochloride.
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