Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-9629966-B2
Publication Date
2017-04-25
Expiration Date
Abstract
An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue/organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue/organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.
Core Innovation
The invention relates to delivering dry powder to an internal operation site of beings using an elongated tubular delivery channel having an emitting opening positioned adjacent to the internal operation site. A distal end of the delivery channel is extended to the position where the emitting opening is adjacent to the site so that a spray can be applied at the site. Dry powder is mixed with pressurized gas and delivered through the delivery channel until a predetermined amount sprays out from the emitting opening for application onto the internal operation site.
A gas powder chamber is used in which pressurized gas is mixed with dry powder so that a mixture of dry powder and pressurized gas is delivered from the gas powder chamber into the delivery channel. The method generates a working gas flow containing pressurized gas to mix with the dry powder and deliver the mixture into the delivery channel for spraying from the emitting opening. In addition, the invention generates a maintaining gas flow to the delivery channel for preventing gas reflux of the delivery channel so as to prevent reflux of gas and fluid into the delivery channel.
To avoid reflux while maintaining the powder-gas mixture delivery, the method bypasses the maintaining gas flow to the gas powder chamber so that the maintaining gas flow does not pass through the gas powder chamber. The method further includes generating the pressurized gas flow and dividing it into the working gas flow and the maintaining flow, with the working gas flow provided to mix with dry powder in the gas powder chamber and the maintaining gas flow generated to prevent reflux into the delivery channel. In further refinement, the working gas flow and the maintaining gas flow are generated from a single gas supplying source.
Claims Coverage
The patent includes two independent claims that share a common architecture: an elongated tubular delivery channel adjacent to an internal operation site, a gas powder chamber for mixing dry powder with pressurized gas for spraying, and a maintaining gas flow to prevent gas reflux into the delivery channel while bypassing that maintaining flow around the gas powder chamber. Across the independent claims, the coverage includes between-workflow gas mixing/spraying and an anti-reflux maintaining gas flow generated from a single gas supplying source.
Reflux-preventing maintaining gas with bypass around the gas powder chamber
Generating a maintaining gas flow to the delivery channel for preventing gas reflux so as to prevent reflux of gas and fluid into the delivery channel, and bypassing the maintaining gas flow to the gas powder chamber such that the maintaining gas flow does not pass through the gas powder chamber.
Working gas mixing with dry powder in a gas powder chamber for spraying at an internal operation site
Generating a working gas flow containing pressurized gas to mix with dry powder, wherein the pressurized gas is mixed with the dry powder in a gas powder chamber and a mixture of dry powder and pressurized gas is delivered to the delivery channel until a predetermined amount sprays out from an emitting opening adjacent to the internal operation site for application onto the internal operation site.
Single gas supplying source split into working gas flow and maintaining flow
Generating a flow of pressurized gas and dividing the pressurized gas into a working gas flow and a maintaining flow, wherein the working gas flow and the maintaining gas flow are generated from a single gas supplying source.
Across the two independent claims, the inventive coverage centers on delivering a dry powder/pressurized-gas mixture from a gas powder chamber into an elongated tubular delivery channel for spraying at an internal operation site, while preventing reflux using a maintaining gas flow that is bypassed so it does not pass through the gas powder chamber. One independent claim further constrains the arrangement by generating working gas flow and maintaining flow from a single gas supplying source.
Stated Advantages
Prevents gas reflux of the delivery channel to prevent reflux of gas and fluid into the delivery channel.
Documented Applications
Application onto an internal operation site as described for delivering dry powder, including hemostasis using SAPH (starch-derived absorbable polysaccharide hemostat) as a hemostatic powder and therapies using powders such as anti-inflammatory, anti-ulcer, and anti-neoplastic therapies.
Interested in licensing this patent?