Virucidal composition
Inventors
Biering, Holger • Denzin, Silke • von Rheinbaben, Friedrich • Meyer, Bernhard
Assignees
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Publication Number
US-9603361-B2
Publication Date
2017-03-28
Expiration Date
Abstract
The invention relates to a virucidal composition comprising based on the compositionfrom 80 to 99 wt-% of a C2-C4 monoalcohol or a mixture thereof,from 0.1 to lower 2 wt-% of an organic acid,from 0.1 to 1 wt-% of an alkoxylated monoglyceride and/or alkoxylated diglyceride,wherein the pH value of the composition is from pH 3.3 to 5 and the remainder up to 100 wt-% is water.The invention further describes a method of inactivating viruses, and a product comprising the virucidal composition and means for applying it.
Core Innovation
The invention relates to a method for the inactivation of viruses by applying an aqueous composition to a virus contaminated surface for a time sufficient to reduce the virus titre at least 4 log10 steps. The virus contaminated surface is human or animal skin, and the composition comprises 80 to 99 wt-% of a C2-C4 monoalcohol or a mixture thereof, together with an organic acid, an alkoxylated monoglyceride or alkoxylated diglyceride, and butanone, with water as the remainder.
The composition has a pH value from 3.3 to 5, and the antimicrobial components further comprise from 0.1 to about 2 wt-% of an organic acid, from 0.1 to 1 wt-% of an alkoxylated monoglyceride or alkoxylated diglyceride, and from about 0.1 to about 3 wt.% of butanone. The document frames the approach against prior art insufficiencies in virus activity and constraints associated with pH and skin irritation.
Increased virucidal efficacy is achieved by including alkoxylated glycerides together with the specified C2-C4 monoalcohol, organic acid, butanone, and pH range. The described performance is exemplified for difficult non-enveloped viruses such as Poliovirus and SV40, and the formulation can be provided as liquid, gel, foam, or emulsion and applied with devices such as a dispenser or spray, including contacting skin with a soaked support.
Claims Coverage
The independent claim defines one inventive method centered on virus inactivation on human or animal skin using a specific aqueous antimicrobial composition. It combines the defined composition, the pH range, and application for a time sufficient to achieve at least a 4 log10 virus titre reduction.
Skin virus inactivation by applying a composition for time sufficient for 4 log10 reduction
Applying a composition to a virus contaminated surface for a time sufficient to reduce the virus titre at least 4 log10 steps, wherein the virus contaminated surface is human or animal skin.
C2-C4 monoalcohol-based antimicrobial composition with defined organic acid, alkoxylated glycerides, and butanone
An aqueous composition wherein the antimicrobial components consist of, by weight of the composition, from 80 to 99 wt-% of a C2-C4 monoalcohol or a mixture thereof, from 0.1 to about 2 wt-% of an organic acid, from 0.1 to 1 wt-% of an alkoxylated monoglyceride or alkoxylated diglyceride, and from about 0.1 to about 3 wt.% of butanone, and wherein water is the remainder.
pH-limited composition for skin compatibility
The composition having a pH value from pH 3.3 to 5.
Optional additives within the composition
Optionally one or more additives selected from stabilizers, fragrance, colorants, emulsifiers, thickeners, wetting agents, or mixtures thereof.
The inventive coverage centers on a C2-C4 monoalcohol-dominant aqueous formulation supplemented with specified organic acid, alkoxylated monoglyceride or diglyceride, and butanone, controlled to a pH of 3.3 to 5, and applied to human or animal skin for enough time to reach at least a 4 log10 reduction of virus titre. The dependent claims further narrow virus types, acid selection, contact-time performance, pH sub-ranges, butanone identity, and formulation refinements.
Stated Advantages
Increased virucidal efficacy is achieved by adding alkoxylated glycerides together with the specified C2-C4 monoalcohol, organic acid, butanone, and pH range.
The method provides at least a 4 log10 virus titre reduction on human or animal skin.
The approach is asserted to address difficult non-enveloped viruses such as Poliovirus and SV40.
Documented Applications
Virucidal hand disinfection/inactivation of viruses on human or animal skin contaminated surfaces by applying the defined aqueous composition for sufficient time to achieve at least a 4 log10 reduction.
Use of the composition as a skin/hand disinfectant formulated as liquid, gel, foam, or emulsion and applied via dispenser or spray, including contacting skin with a soaked support.
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