Chronic wound dressing with added anti-scar compound
Inventors
Woodroof, E. Aubrey • Phipps, Richard R.
Assignees
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Publication Number
US-9585793-B2
Publication Date
2017-03-07
Expiration Date
Abstract
An improved skin substitute is presented comprised of a silicone layer backed up with a woven nylon fabric layer, the silicone layer possessing a regular pattern of slits that permit the porosity of the skin substitute to be adjusted by clinicians by means of applying tension to the skin substitute that differentially opens the slits. A variety of therapeutic substances can be applied to the skin substitute to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being salinomycin.
Core Innovation
The disclosure relates to a skin substitute and chronic wound dressing having a silicone membrane upper layer and a woven nylon fabric lower layer. The upper layer has a plurality of slits in a surface, formed after the two layers are joined together, in a regular pattern comprising alternating perpendicular orientation with horizontal and vertical orientations, and the slit pattern is configured with respect to the wale and course orientation of the woven nylon fabric.
The skin substitute has essentially zero porosity when no stretching tension is placed on it, and variable porosity proportional to the amount of stretching tension and the direction in which the stretching tension is placed. The direction of stretching tension is dependent on the orientation of the slits with the wale and course orientation of the woven nylon fabric, and the woven nylon fabric side is placed down on top of a wound when in use.
Both the silicone membrane and the woven nylon fabric are treated with a plurality of layers of medicinal or therapeutic substances applied to the two layers of the skin substitute. The lower layer is also treated with a water soluble or water insoluble anti-scar compound, including salinomycin, which is incorporated either into a hydrophobic solid silicone component or into a water-soluble biological coating.
Claims Coverage
The partial content provides one independent claim (clm-00001). The claim covers a two-layer skin substitute with a regularly patterned, tension-responsive slitted silicone membrane matched to woven nylon orientation, with multi-layer medicinal or therapeutic substances and an anti-scar compound on the lower layer, and use in combination with an absorptive dressing.
Two-layer skin substitute with silicone membrane and woven nylon fabric
A skin substitute comprised of an upper layer comprised of a silicone membrane and a lower layer comprised of a woven nylon fabric.
Regularly patterned slits configured by orientation
The silicone membrane upper layer has a plurality of slits in its surface, made after the two layers are joined together, in a regular pattern comprising alternating perpendicular orientation with horizontal and vertical orientations, where the slits follow or cross the wale direction of the woven nylon fabric.
Zero porosity without tension and variable porosity with stretch tension
The slits are placed in the upper layer such that the skin substitute has essentially zero porosity with no stretching tension placed on it, and porosity is variable proportional to the amount of stretching tension and the direction in which said stretching tension is placed on the skin substitute.
Layer placement and combination with absorptive dressing
The skin substitute is used with the woven nylon fabric side down on top of a wound and in combination with an absorptive dressing placed above said skin substitute over the wound.
Multi-layer medicinal or therapeutic substances plus anti-scar treatment
Both the upper layer and the lower layer are treated with a plurality of layers of medicinal or therapeutic substances, and the lower layer is also treated with a water soluble or water insoluble anti-scar compound.
Salinomycin anti-scar compound and incorporation location
The anti-scar compound is salinomycin, and salinomycin is incorporated either into a hydrophobic solid silicone component or into a water-soluble biological coating.
Overall, the claim coverage centers on a tension-responsive silicone membrane with regularly patterned slits aligned to woven nylon orientation to provide essentially zero porosity without tension and variable porosity with stretch tension. It also requires multi-layer medicinal or therapeutic coatings on both layers, an anti-scar compound on the lower layer, and specifies salinomycin and its incorporation into either the silicone component or a water-soluble biological coating.
Stated Advantages
Documented Applications
Use of the skin substitute in combination with an absorptive dressing placed above the skin substitute over a wound, with the woven nylon fabric side placed down on top of a wound when in use.
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