Balloon catheter with polymeric balloon having a surface modified by a photoactivation reaction and method of making
Inventors
D'Onofrio, Simone • PELLEGRINI, PAOLO
Assignees
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Publication Number
US-9550047-B2
Publication Date
2017-01-24
Expiration Date
Abstract
A balloon catheter, in particular a balloon catheter for angioplasty, the balloon having an inner or outer surface modified by means of a photoactivation reaction.
Core Innovation
The invention relates to a balloon catheter having a balloon made of a polymeric material whose surface is modified by photoactivation of substituted aromatic azides. The photoactivation generates azide-derived nitrene intermediates that are covalently inserted into C–H bonds of the polymer, so that covalently bound groups are formed on the balloon surface.
The covalently bound groups impart desired surface characteristics by providing hydrophilic or hydrophobic properties. Hydrophilic modification is intended to reduce friction and improve slidability, while hydrophobic modification is intended to support improved occlusion penetration and anti-adhesion between polymer layers and folds, including effects related to shelf-life adhesion.
The modified balloon surface can further be used to bind an active substance directly to the outer surface or via a bridge substance such as a nanoparticle carrier. The document also includes dynamic contact angle evaluation showing that photoactivation significantly changes advancing and receding contact angles on both plate and balloon geometries, consistent with reduced or increased hydrophilicity depending on the substituted aromatic azide chemistry.
Claims Coverage
The independent claims present one main inventive feature in the provided claim text: a balloon catheter with a polymer surface having covalently bound groups defined by a chemical formula and substituent constraints. Dependent claim coverage further adds binding of active substances to the balloon outer surface and defines bridge substances for attaching those active substances.
Covalently bound groups on a polymer balloon surface
A balloon catheter with a balloon made of a polymeric material, where the balloon surface comprises covalently bound groups of the following formula, with each R1 independently H or F, R2 selected from –C(O)NH–Ra, –S(O)2NH–Ra, and –P(O)2NH–Ra, and wherein Ra is selected from specific C1-C4 saturated alkyl chains optionally substituted with polar functional groups or perfluoroalkyl groups (m=1 to 70), specific (CHRCH2O)n–X groups (n=1 to 70, R=H or CH3, X as defined, and p and q ranges), or a C1-C70 saturated alkyl chain or an aromatic compound, with R3 being –NO2.
The core inventive coverage is the functionalized balloon surface formed by covalently bound, formula-defined groups on a polymeric balloon surface, with dependent coverage for active substance binding and bridge substances.
Stated Advantages
Reduces friction and improves slidability via hydrophilic surface modification.
Improves occlusion penetration via hydrophobic surface modification.
Provides anti-adhesion between polymer layers and folds, including improved shelf-life adhesion.
Documented Applications
Angioplasty and endovascular intervention using the balloon catheter with modified balloon surface properties.
Drug eluting balloon use cases by binding drug/therapeutic active substances to the balloon surface directly or via bridge substances such as nanoparticles.
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