Biodegradable medical devices and method to control degradation of the biodegradable medical devices

Inventors

Doshi, Manish • Gandhi, Pankaj • Choksi, Ronak • Sojitra, Prakash

Assignees

Envision Scientific Pvt Ltd

Abstract

An implantable biodegradable device having two or more layers composed of one or more biodegradable materials is disclosed. The two or more layers are coated with one or more drugs. The implantable biodegradable device further having one or more inert layers is composed of a biodegradable material. The one or more inert layers of the implantable biodegradable device are degraded in response to introduction of one or more external triggers when the implantable biodegradable medical device is placed within a living organism. Further, a layer of the two or more layers having a position above an inert layer is degraded prior to degradation of the inert layer. Subsequently, a layer of the two or more layers having a position below the inert layer is degraded subsequent to degradation of the inert layer.

Core Innovation

The invention relates to an implantable biodegradable medical device comprising a rigid member with an inner surface and an outer surface. The rigid member includes at least one inert layer capable of providing axial strength and radial rigidity, and a plurality of biodegradable layers on the outer surface and a plurality of biodegradable layers on the inner surface, where the biodegradable layers are coated with corresponding at least one drug.

The at least one inert layer is composed of a material not biodegradable unless triggered, and remains inert to provide the axial strength and the radial rigidity until the plurality of layers on the outer surface have degraded to release the corresponding at least one drug, thereby exposing the at least one inert layer. After exposure, the inert layer remains inert until degradation of the at least one inert layer is initiated by at least one external trigger.

The layer degradation is temporally ordered, with layers positioned above the inert layer degrading before the inert layer, and layers below the inert layer degrading after the inert-layer degradation is initiated. Exposure of the inner layers occurs when degradation of the at least one inert layer exposes the plurality of layers on the inner surface, and the inner-surface biodegradable layers remain intact without releasing the corresponding at least one drug until that exposure.

Claims Coverage

The independent claim covers an implantable biodegradable medical device with inert inner/outer structures, where drug-coated biodegradable layers degrade to release drugs only after sequential exposure events, while an inert layer maintains mechanical properties until an external trigger initiates its degradation. The inventive features include inert-layer mechanical support maintained until outer biodegradable layers degrade, and inner-layer drug release deferred until inert-layer degradation exposes the inner layers.

Overall, the claim set focuses on maintaining mechanical axial strength and radial rigidity with an inert layer until sequential degradation and exposure events occur, enabling outer drug release prior to inert-layer degradation and deferring inner drug release until inert-layer degradation exposes the inner biodegradable layers.

Stated Advantages

Documented Applications

No documented applications found