Antioxidant composition
Inventors
Castro Feo, Maria Begoña • Azcoitia Ramsden, Iker • Palomares Casado, Teodoro • Herrero De Miguel, Jone • Alonso Varona, Ana Isabel • Del Olmo Basterrechea, Maite
Assignees
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Publication Number
US-9492475-B2
Publication Date
2016-11-15
Expiration Date
Abstract
The present invention relates to an antioxidant composition comprising a combination of galatomannan and N-acetyl cysteine for its use in the treatment of a skin disease or condition resulting from reactive oxygen species production in the skin or involving reactive oxygen species production in the skin, to a hydrogel containing said combination as well as to dressing wounds comprising said hydrogel and its use in the healing of ulcers, wounds, burns and scalds.
Core Innovation
The invention relates to an antioxidant composition comprising galactomannan, N-acetyl cysteine, and curcumin. In the described embodiments, galactomannan is preferably locust bean gum, and the combination provides antioxidant activity in oxidative-stress conditions affecting skin-relevant cells.
The partial content further describes an antioxidant effect in oxidative-stress fibroblast models, including increased cell survival and reduced intracellular reactive oxygen metabolites. The described oxidative-stress context is linked to reactive oxygen species and oxidative stress associated with skin conditions.
The invention also provides cross-linked galactomannan matrices forming hydrogels that incorporate N-acetyl cysteine and optionally curcumin. The disclosed hydrogel construction includes a cross-linked galactomannan matrix and can incorporate curcumin via matrix absorption and/or xerogel rehydration, for use in topical/medicament and wound-dressing contexts.
Claims Coverage
The independent claims focus on a defined antioxidant composition with a three-component combination, and one dependent claim further specifies cosmetically acceptable components.
Antioxidant composition comprising galactomannan, N-acetyl cysteine, and curcumin
An antioxidant composition comprising galactomannan, N-acetyl cysteine, and curcumin.
Cosmetically acceptable components in the antioxidant composition
The antioxidant composition of the preceding claim further includes cosmetically acceptable components.
Overall, the claim coverage centers on a defined antioxidant composition combining galactomannan, N-acetyl cysteine, and curcumin, optionally extended with cosmetically acceptable components.
Stated Advantages
In oxidative-stress fibroblast models, increased cell survival is observed.
In oxidative-stress fibroblast models, reduced intracellular reactive oxygen metabolites are observed.
Documented Applications
Topical skin treatment for ROS-related skin damage and oxidative-stress contexts.
Hydrogel wound dressing/medicament for wounds including ulcers, burns, scalds, acute surgical/traumatic wounds, diabetic ulcers, and pressure sores/decubitus ulcers.
Cosmetic composition for UV radiation protector and photoaging-related contexts.
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