Collagen powder, composition and use
Inventors
Assignees
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Publication Number
US-9474718-B2
Publication Date
2016-10-25
Expiration Date
Abstract
Collagen powder in which at least 99.5% of the particles have a maximum size of 80 microns 25% to 45% by volume of the particles have a size of more than 30 microns and 35% to 50% by volume of the particles have a size in the range of 20 to 70 microns.
Core Innovation
The invention relates to a collagen powder defined by a particle-size distribution in which at least 99.5% of the particles have a maximum size of 80 microns, and 25% to 45% by volume of the particles have a size of more than 30 microns. Preferred embodiments further define additional volume fractions across size brackets, including 15% to 22% by volume for particles having a size of more than 40 microns and 8% to 13% by volume for particles having a size of more than 50 microns, while limiting fine particles to 10% by volume or less for particles of 10 microns or less.
The collagen powder includes Type I native collagen obtained from horse tendons and/or bovine tendons. The document provides a rationale that using larger particles together with the full size distribution provides improved wound-healing performance while still enabling spray uniformity and long-term stability, described as avoiding clumping or aggregate formation.
The disclosed collagen powder is used to support wound-healing compositions, including spray formulations containing appropriate propellants and carriers, with optional adjuvants such as colloidal silver. The document reports improved wound healing outcomes including faster reduction of wound area and reduced wound exudate volume, and further reports use in diaper dermatitis with effectiveness that is at least comparable to zinc oxide via spray administration.
Claims Coverage
The independent claim covers a collagen powder defined by a specific particle-size profile, including an upper maximum particle size and defined volume fractions above a threshold size. The claim set further refines the particle-size distribution, specifies the collagen identity, and includes formulated compositions with defined carriers.
Particle-size distribution with maximum size limit
A collagen powder wherein at least 99.5% of the particles have a maximum size of 80 microns.
Volume fraction of particles larger than 30 microns
A collagen powder wherein 25% to 45% by volume of the particles have a size of more than 30 microns.
Refined volume fraction in the 30+ micron range
A collagen powder wherein 30% to 35% by volume of the particles have a size of more than 30 microns.
Refined volume fraction for particles larger than 40 microns
A collagen powder wherein the volume fraction of particles having a size greater than 40 microns is between 15% and 22% by volume.
Fine-particle limitation for particles 10 microns or less
A collagen powder wherein particles sized 10 microns or less make up 10% by volume or less.
Type I collagen from horse and/or bovine tendons
A collagen powder wherein the collagen is type I collagen obtained from horse and/or bovine tendons.
Carrier selected from specific particulate materials
The composition uses a carrier selected from rice starch, maize starch, kaolin, zeolites, or mixtures thereof.
Overall, the claims center on a collagen powder defined by a constrained particle-size distribution, with further refinement to limit fine particles and specify Type I native collagen from horse and/or bovine tendons. Additional coverage includes formulated compositions using defined carriers, including named particulate carriers.
Stated Advantages
Improved wound-healing performance, including faster reduction of wound area.
Reduced wound exudate volume.
Improved spray uniformity.
Long-term stability described as avoiding clumping or aggregate formation.
Effectiveness in diaper dermatitis at least comparable to zinc oxide when administered as a spray.
Documented Applications
Wound-healing applications using spray compositions containing the collagen powder, with reported faster reduction of wound area and reduced wound exudate volume.
Diaper dermatitis, where spray administration of the collagen powder composition is reported to be at least comparable to zinc oxide.
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