Partially hydrolyzed casein-whey nutritional compositions for reducing the onset of allergies
Inventors
Vanderhoof, Jon A. • Scalabrin, Deolinda
Assignees
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Publication Number
US-9474298-B2
Publication Date
2016-10-25
Expiration Date
Abstract
The present disclosure relates to methods of reducing the onset of allergies. In certain embodiments, the method includes administering to an infant a nutritional composition that includes a fat or lipid source, a carbohydrate source, a protein source comprising whey and casein proteins and, optionally, a probiotic. In certain embodiments, the whey:casein ratio in the protein source is from about 50:50 to about 70:30 and the degree of hydrolysis of the proteins included in the protein source is from about 4% to about 10%.
Core Innovation
The invention relates to methods of increasing the concentration of fecal secretory IgA in a child having an allergic reaction to at least one antigen, wherein the child is at least two years of age or older. The method includes exposing the child, when the child is an infant, to an antigen selected from cow's milk, egg, soy, house dust, and mites, and administering to the child, when the child is an infant, a nutritional composition.
The nutritional composition contains defined amounts of fat or lipid source and a carbohydrate source comprising between 15% and 55% lactose by weight. The nutritional composition further includes a probiotic source comprising Lactobacillus rhamnosus GG and a non-human lactoferrin, together with a prebiotic source comprising galactooligosaccharide and polydextrose.
The invention also relates to inducing oral tolerance in a child having an allergic reaction to at least one antigen, wherein the child is at least two years of age or older. The method includes exposing the child, when the child is an infant, to an antigen selected from cow's milk, egg, soy, house dust, and mites, administering the same defined nutritional composition during infancy, and subsequently exposing the child to the at least one antigen.
Claims Coverage
The partial claim set contains three independent claims. Each independent claim centers on infant exposure to an antigen followed by administration of a defined nutritional composition with specified macronutrient ranges and protein processing characteristics, and one independent claim includes subsequent antigen exposure for oral tolerance.
Increasing fecal secretory IgA by infant antigen exposure and defined nutritional composition
A method of increasing the concentration of fecal secretory IgA in a child having an allergic reaction to at least one antigen, wherein the child is at least two years of age or older, comprising exposing the child, when the child is an infant, to the antigen selected from cow's milk, egg, soy, house dust, and mites, and administering, during infancy, a nutritional composition comprising specified fat or lipid amount, carbohydrate source with between 15% and 55% lactose by weight, a probiotic source comprising Lactobacillus rhamnosus GG, a non-human lactoferrin, a prebiotic source comprising galactooligosaccharide and polydextrose at 0.1 g/100 kcal to 1 g/100 kcal, and a protein source comprising whey and casein proteins at 1 g/100 kcal to 5 g/100 kcal with whey:casein 50:50 to 70:30 by weight and degree of hydrolysis 4% to 10%.
Inducing oral tolerance by infant antigen exposure and defined nutritional composition
A method of inducing oral tolerance in a child having an allergic reaction to at least one antigen, wherein the child is at least two years of age or older, comprising exposing the child, when the child is an infant, to the antigen selected from cow's milk, egg, soy, house dust, and mites, and administering, during infancy, a nutritional composition comprising specified fat or lipid amount, carbohydrate source with between 15% and 55% lactose by weight, a probiotic source comprising Lactobacillus rhamnosus GG, a non-human lactoferrin, a prebiotic source comprising galactooligosaccharide and polydextrose at 0.1 g/100 kcal to 1 g/100 kcal, and a protein source comprising whey and casein proteins at 1 g/100 kcal to 5 g/100 kcal with whey:casein 50:50 to 70:30 by weight and degree of hydrolysis 4% to 10%.
Inducing oral tolerance by infant administration followed by subsequent antigen exposure
A method of inducing oral tolerance in a child having an allergy to at least one antigen, wherein the child is at least two years of age or older, comprising exposing the child, when the child is an infant, to the antigen selected from cow's milk, egg, soy, house dust, and mites, administering, during infancy, a nutritional composition comprising specified fat or lipid amount, carbohydrate source with between 15% and 55% lactose by weight, a probiotic source comprising Lactobacillus rhamnosus GG, lactoferrin from a non-human source, a prebiotic source comprising galactooligosaccharide and polydextrose at 0.1 g/100 kcal to 1 g/100 kcal, and a protein source comprising whey and casein proteins at 1 g/100 kcal to 5 g/100 kcal with whey:casein 50:50 to 70:30 by weight and degree of hydrolysis 4% to 10%, and subsequently exposing the child to the at least one antigen.
Across the independent claims, the core coverage is a defined nutritional composition administered during infancy after infant exposure to specific antigens, with quantitative constraints on carbohydrate lactose content, prebiotic composition and amount, probiotic source, non-human lactoferrin, and protein characteristics. Oral tolerance induction additionally includes subsequent exposure to the antigen in one independent claim.
Stated Advantages
Increasing the concentration of fecal secretory IgA.
Inducing oral tolerance.
Documented Applications
Methods to increase fecal secretory IgA in a child with an allergic reaction to an antigen selected from cow's milk, egg, soy, house dust, and mites.
Methods to induce oral tolerance in a child with an allergic reaction to an antigen selected from cow's milk, egg, soy, house dust, and mites, including subsequent antigen exposure in one method.
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