Temporarily stiffened mesh prostheses
Inventors
Buevich, Fatima • Do, Frank • McJames, William • Pulapura, Satish • Edelman, William • Moses, Arikha • Diamond, Mason • Timothy, Shari
Assignees
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Publication Number
US-9457129-B2
Publication Date
2016-10-04
Expiration Date
Abstract
The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
Core Innovation
The invention describes a medical prosthesis comprising a porous surgical mesh with biodegradable or resorbable polymer coatings that comprise tyrosine-derived diphenol monomer units. The coatings are applied without substantially altering mesh porosity, and the prosthesis ameliorates or mitigates a soft tissue defect. The supplied partial content does not include the background section text, so it does not explicitly describe the problem stated there.
The document also describes coatings that temporarily immobilize contact points of mesh filaments or fibers to stiffen the mesh, and coatings that maintain a three-dimensional mesh shape. The coatings may comprise polymers from the P22-xx family and therapeutic agents, including rifampin and minocycline; the description also reports antimicrobial and bupivacaine release. The supplied content describes stiffness decreasing as the coating degrades.
Claims Coverage
The provided relevant claims include three independent claims representing three inventive features: claim 1, claim 26, and claim 42. They cover a coated porous mesh prosthesis for soft-tissue defects, a biodegradable polymer stiffening coating that temporarily immobilizes filament or fiber contact points, and a drug-containing P22-xx-coated porous mesh.
Porous mesh prosthesis with tyrosine-derived polymer coatings
Claim 1 covers a medical prosthesis comprising a porous surgical mesh with one or more biodegradable or resorbable polymer coatings comprising tyrosine-derived diphenol monomer units. The coatings are applied without substantially altering mesh porosity, and the prosthesis ameliorates or mitigates a soft tissue defect.
Biodegradable polymer coating that temporarily immobilizes mesh contact points
Claim 26 covers a mesh coated with a stiffening agent that coats filaments or fibers to temporarily immobilize their contact points. The stiffening agent comprises biodegradable polymers containing tyrosine-derived diphenol monomer units.
P22-xx-coated mesh containing rifampin and minocycline
Claim 42 covers a porous surgical mesh with biodegradable or resorbable polymer coatings applied without substantially altering mesh porosity. The coatings comprise a P22-xx family polymer having 5–50% DT, as well as rifampin and minocycline.
The three independent claims cover porosity-preserving polymer coatings for a soft-tissue prosthesis, biodegradable coatings that temporarily stiffen mesh by immobilizing filament or fiber contact points, and P22-xx coatings containing rifampin and minocycline.
Stated Advantages
The coatings are applied without substantially altering the porosity of the porous surgical mesh.
The prosthesis ameliorates or mitigates a soft tissue defect.
The coatings temporarily stiffen the mesh by immobilizing contact points of its filaments or fibers.
The coatings maintain a three-dimensional shape of the mesh.
Documented Applications
Soft-tissue repair, including reconstruction, reinforcement, bridging, replacement, repair, support, stabilization, positioning, or strengthening of a soft tissue defect.
Localized antimicrobial delivery from the coated mesh, including delivery of rifampin and minocycline.
Localized analgesic delivery from the coated mesh; the partial content describes bupivacaine release.
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