Nutritional composition containing a peptide component with anti-inflammatory properties and uses thereof
Inventors
Hondmann, Dirk • van Tol, Eric A. F. • Gross, Gabriele • Schoemaker, Marieke H. • Lambers, Teartse Tim
Assignees
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Publication Number
US-9457058-B2
Publication Date
2016-10-04
Expiration Date
Abstract
The present disclosure relates to nutritional compositions comprising a protein equivalent source, wherein 20% to 80% of the protein equivalent source includes a peptide component comprising SEQ ID NO 4, SEQ ID NO 13, SEQ ID NO 17, SEQ ID NO 21, SEQ ID NO 24, SEQ ID NO 30, SEQ ID NO 31, SEQ ID NO 32, SEQ ID NO 51, SEQ ID NO 57, SEQ ID NO 60, and SEQ ID NO 63, and 20% to 80% of the protein equivalent source comprises an intact protein, a partially hydrolyzed protein, or combinations thereof. The disclosure further relates to methods of reducing the inflammatory response and/or production of proinflammatory cytokines, i.e. Interleukin-17, by providing said nutritional compositions to a target subject.
Core Innovation
The invention relates to a nutritional composition comprising a carbohydrate source, a fat source, and a protein equivalent source, in which the protein equivalent source includes a defined peptide component and defined intact/partially hydrolyzed protein fractions. The peptide component includes specified peptides identified by SEQ ID NO 4, SEQ ID NO 13, SEQ ID NO 17, SEQ ID NO 21, SEQ ID NO 24, SEQ ID NO 30, SEQ ID NO 32, SEQ ID NO 51, SEQ ID NO 57, SEQ ID NO 60, and SEQ ID NO 63, and further comprises at least 3 additional individual peptides selected from Table 1.
The composition further defines how the peptide and protein portions are formulated within the protein equivalent source, specifically stating that 20% to 80% of the protein equivalent source includes the peptide component and that 20% to 80% of the protein equivalent source comprises intact protein and a partially hydrolyzed protein. In one independent claim, at least 20% of the protein equivalent source comprises a casein hydrolysate having a molar mass distribution of greater than 500 Daltons.
The described nutritional compositions are directed to reducing inflammatory responses, particularly by modulating IL-17 and proinflammatory cytokine production, including IL-12, IL-6, and TNF-α. The disclosures include definition of peptide/protein terms such as degree of hydrolysis and molar mass distribution thresholds, and they provide broad nutritional formulation ranges per 100 kcal for carbohydrate, fat, and protein equivalent components.
Claims Coverage
The provided claims include two independent claims, each covering a nutritional composition defined by carbohydrate source, fat source, and a protein equivalent source whose protein fraction is partitioned into a specified peptide component and intact/partially hydrolyzed protein. Across the independents, the inventive structure centers on the defined set of SEQ ID peptides plus additional peptides from Table 1, combined with intact and partially hydrolyzed protein and, in one independent, a molar mass distribution threshold for a casein hydrolysate fraction.
Protein equivalent source partitioned into peptide component and intact/partially hydrolyzed protein
A nutritional composition wherein 20% to 80% of the protein equivalent source includes a peptide component comprising peptides identified by SEQ ID NO 4, SEQ ID NO 13, SEQ ID NO 17, SEQ ID NO 21, SEQ ID NO 24, SEQ ID NO 30, SEQ ID NO 32, SEQ ID NO 51, SEQ ID NO 57, SEQ ID NO 60, and SEQ ID NO 63, further wherein the peptide component comprises at least 3 additional individual peptides selected from Table 1, and wherein 20% to 80% of the protein equivalent source comprises an intact protein and a partially hydrolyzed protein.
Per-100-kcals nutritional ranges with defined peptide component and casein hydrolysate molar mass distribution
A nutritional composition comprising per 100 kcals from about 5 g to about 25 g of a carbohydrate source, from about 1.3 g to about 7.2 g of a fat source, and from about 1 g to about 7 g of a protein equivalent source, wherein 20% to 80% of the protein equivalent source comprises a peptide component comprising peptides identified by SEQ ID NO 4, SEQ ID NO 13, SEQ ID NO 17, SEQ ID NO 21, SEQ ID NO 24, SEQ ID NO 30, SEQ ID NO 32, SEQ ID NO 51, SEQ ID NO 57, SEQ ID NO 60, and SEQ ID NO 63 with at least 3 additional individual peptides selected from Table 1, and wherein at least 20% of the protein equivalent source comprises a casein hydrolysate having a molar mass distribution of greater than 500 Daltons.
Overall, the independent claim coverage is directed to nutritional compositions where a defined peptide component is present as 20% to 80% of the protein equivalent source, paired with defined intact protein/partially hydrolyzed protein and, in one independent claim, a casein hydrolysate molar mass distribution greater than 500 Daltons.
Stated Advantages
Reduces inflammatory responses, particularly IL-17 and proinflammatory cytokine production.
Documented Applications
Infant formula.
Pediatric subject growing-up milk.
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