Skin substitute and wound dressing with added anti-scar compound
Inventors
Woodroof, E. Aubrey • Phipps, Richard R.
Assignees
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Publication Number
US-9439808-B2
Publication Date
2016-09-13
Expiration Date
Abstract
An improved skin substitute is presented comprised of a silicone layer backed up with a woven nylon fabric layer, the silicone layer possessing a regular pattern of slits that permit the porosity of the skin substitute to be adjusted by clinicians by means of applying tension to the skin substitute that differentially opens the slits. A variety of therapeutic substances can be applied to the skin substitute to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being salinomycin.
Core Innovation
The invention relates to an improved skin substitute for acute or chronic wounds. The skin substitute is comprised of two layers, with an upper layer including a silicone membrane and a lower layer including a woven nylon fabric, and the silicone membrane has a selected thickness from 0.001" to 0.005".
The upper silicone membrane layer possesses a plurality of slits in its surface, where the slits are made after the two layers are joined together. The slit pattern is comprised of multiple rows of parallel slits, and the lower layer is woven in a regular pattern with a perpendicular wale and course orientation, so the direction of stretching tension is dependent on the orientation of the slits with the wale and course orientation.
The skin substitute is configured such that it has essentially zero porosity with no stretching tension placed on it, and the porosity is variable and proportional to the amount of stretching tension and the direction in which the stretching tension is placed. Both layers are treated with a plurality of layers of medicinal or therapeutic substances, and the lower layer is also treated with a water soluble or water insoluble anti-scar compound.
The skin substitute is designed to place the woven nylon fabric side down on top of a wound when in use, and is selected to be used in combination with an absorptive dressing placed above the skin substitute over the wound. The invention further includes medicinal or therapeutic substances applied as plurality of layers on the two layers of the skin substitute, including hypoallergenic BSE-free USP-grade gelatin and aloe/aloe compounds, with optional ECM.
Claims Coverage
The disclosed independent claim covers a two-layer skin substitute and its structural and functional relationships that control porosity, together with specified medicinal or therapeutic treatment layers and an anti-scar treatment for the wound application. The claim includes five inventive features that collectively define the layer construction, slit patterning and orientation, variable porosity by stretching tension, treatment composition layering, and specified wound placement with an absorptive dressing.
Two-layer skin substitute with silicone membrane and woven nylon fabric
A skin substitute comprised of two layers: an upper layer having a silicone membrane and a lower layer comprising a woven nylon fabric, where the silicone membrane is selected in a thickness from 0.001" to 0.005".
Slit pattern formed after joining and aligned with wale/course orientation
The upper layer possesses a plurality of slits in its surface, said slits made after the two layers are joined together, with a pattern comprised of multiple rows of parallel slits, and the lower layer woven in a regular pattern with perpendicular wale and course orientation where the slits either follow the wale direction or cross the wale direction perpendicularly.
Variable porosity controlled by stretching tension magnitude and direction
The skin substitute has essentially zero porosity with no stretching tension placed on it, where porosity of the skin substitute is variable proportional to the amount of stretching tension and the direction in which said stretching tension is placed, and the direction is dependent on the orientation of the slits with the wale and course orientation of the woven nylon fabric.
Medicinal or therapeutic multi-layer treatment and anti-scar compound on woven nylon layer
The upper layer and the lower layer treated with a plurality of layers of medicinal or therapeutic substances applied to the two layers of the skin substitute, with the lower layer also treated with a water soluble or water insoluble anti-scar compound.
Woven nylon fabric side down and combination with an absorptive dressing
The skin substitute designed to place the woven nylon fabric side down on top of a wound when in use, and selected to be used in combination with an absorptive dressing placed above said skin substitute over the wound.
Across the independent claim, the central inventive scope is a silicone membrane/woven nylon two-layer skin substitute with a joined-after slit pattern whose wale/course-aligned orientation enables essentially zero porosity without stretching tension and variable porosity proportional to stretching tension magnitude and direction, while both layers receive medicinal or therapeutic multi-layer treatment and the woven nylon layer receives a water soluble or water insoluble anti-scar compound, for use with an absorptive dressing over the wound.
Stated Advantages
Provides essentially zero porosity with no stretching tension placed on it.
Provides variable porosity proportional to the amount and direction of stretching tension, dependent on slit orientation relative to wale and course orientation.
Documented Applications
Use of the skin substitute by placing the woven nylon fabric side down on top of a wound and using it in combination with an absorptive dressing placed above the skin substitute over the wound.
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