Nutritional composition to promote healthy development and growth
Inventors
Rosales, Francisco J. • Rai, Gyan P. • Morris, Kristin • Banavara, Dattatreya • van Tol, Eric • Jouni, Zeina E. • McMahon, Robert J. • Schade, Deborah A. • Walker, Donald Carey
Assignees
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Publication Number
US-9386794-B2
Publication Date
2016-07-12
Expiration Date
Abstract
A nutritional composition having a lipid or fat; a protein source; a source of long chain polyunsaturated fatty acids which comprises docosahexanoic acid; and up to about 2.5% by weight of a source of supplemental calcium which, when dissociated, provides a cation having prebiotic functionality.
Core Innovation
The disclosed invention relates to a nutritionally complete nutritional composition that includes a lipid or fat, a bovine milk protein source, and a source of long chain polyunsaturated fatty acids comprising docosahexanoic acid. The composition further includes a supplemental calcium source present in an amount of about 1.0% to about 2.5% by weight, wherein at least 20% of the supplemental calcium source comprises calcium gluconate.
A prebiotic composition is included that provides an increased population of beneficial bacteria in the human gut. The composition comprises polydextrose and at least 20% of galacto-oligosaccharide within the prebiotic composition, and may further include probiotic taxa.
In addition, the nutritional composition further comprises a source of transforming growth factor-β (TGF-β) in a specified amount range. The disclosure also states an equivalence in calcium bioavailability compared with conventional calcium salts including calcium lactate, calcium sulfate, calcium chloride, calcium citrate, and calcium saccharate.
Claims Coverage
Independent claim clm-00001 covers a nutritionally complete nutritional composition with four inventive features: defined lipid/fat, bovine milk protein source, DHA-containing long chain polyunsaturated fatty acid source, supplemental calcium with at least 20% calcium gluconate, a prebiotic composition with specified oligosaccharide components, and a TGF-β source with a specified amount range.
Nutritionally complete composition with defined lipid, bovine milk protein, and DHA-containing long chain polyunsaturated fatty acids
A nutritionally complete nutritional composition comprising about 3 to about 7 g/100 kcal of a lipid or fat, about 1 to about 5 g/100 kcal of a bovine milk protein source, and about 5 to about 100 mg/100 kcal of a source of long chain polyunsaturated fatty acids comprising docosahexanoic acid.
Supplemental calcium with at least 20% calcium gluconate
A nutritionally complete nutritional composition wherein about 1.0% to about 2.5% by weight of a source of supplemental calcium is provided, and wherein at least 20% of the source of supplemental calcium comprises calcium gluconate.
Prebiotic composition with increased beneficial bacteria via polydextrose and galacto-oligosaccharide
A nutritionally complete nutritional composition comprising about 0.2 to about 1.5 mg/100 kcal of a prebiotic composition comprising a plurality of oligosaccharides such that the overall fermentation rate profile provides an increased population of beneficial bacteria in the human gut, wherein the prebiotic composition comprises polydextrose and at least 20% of an oligosaccharide comprising galacto-oligosaccharide.
TGF-β source within a specified amount range
A nutritionally complete nutritional composition further comprising a source of transforming growth factor-β (TGF-β), wherein the amount of TGF-β ranges from about 0.015 to about 0.1 pg/μg.
Overall, the claim coverage is centered on a defined nutritionally complete nutritional composition that combines specific amounts of lipid/fat, bovine milk protein source, DHA-containing long chain polyunsaturated fatty acids, a supplemental calcium source requiring at least 20% calcium gluconate, a prebiotic composition with polydextrose and at least 20% galacto-oligosaccharide to increase beneficial bacteria, and a TGF-β source within a specified amount range.
Stated Advantages
Provides calcium bioavailability equivalent to that of conventional calcium salts including calcium lactate, calcium sulfate, calcium chloride, calcium citrate, and calcium saccharate.
Produces significant effects on growth performance and plasma mineral levels compared with calcium carbonate in the described neonatal pig study.
Bone mechanical testing outcomes favor calcium gluconate.
Documented Applications
Neonatal pig diets comparing calcium carbonate versus calcium gluconate, with and without oligosaccharides, including measured growth performance, plasma mineral levels, and bone mechanical testing outcomes.
A nutritional composition intended for the human gut context through a prebiotic composition that provides an increased population of beneficial bacteria in the human gut.
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