System and method for determining individualized medical intervention for a disease state
Inventors
Von Hoff, Daniel D. • Penny, Robert J.
Assignees
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Publication Number
US-9372193-B2
Publication Date
2016-06-21
Expiration Date
Abstract
A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.
Core Innovation
The invention provides a system for generating a report identifying at least one therapeutic agent for an individual with a cancer. The system includes at least one device configured to assay a plurality of molecular targets in a biological sample to determine molecular profile test values for the plurality of molecular targets, wherein the plurality of molecular targets comprises AR, EGFR, HER2, KIT, MLH1, PTEN, and PDGFRA. The molecular profile test values are used as inputs to compare against reference values.
The system further includes at least one computer database that comprises a reference value for each of the plurality of molecular targets and a listing of available therapeutic agents for each of the plurality of molecular targets. Computer-readable program code inputs the molecular profile test values and compares each molecular profile test value with a corresponding reference value from the database.
Computer-readable program code accesses the database and identifies at least one therapeutic agent from the listing of available therapeutic agents wherein the comparison to the reference values indicates a likely benefit. A computer-readable program code generates a report that comprises a listing of the molecular targets for which the comparison to the reference value indicated a likely benefit of the at least one therapeutic agent, and the at least one therapeutic agent identified from the database.
Claims Coverage
The partial content provides one independent claim. It covers a pipeline that assays multiple specified molecular targets, compares molecular profile test values to database reference values, identifies therapeutic agents associated with likely benefit based on that comparison, and generates a report listing the relevant targets and identified therapeutic agents.
Assaying a specified plurality of molecular targets in a biological sample
A device assays a plurality of molecular targets in a biological sample to determine molecular profile test values for the plurality of molecular targets, wherein the plurality of molecular targets comprises AR, EGFR, HER2, KIT, MLH1, PTEN, and PDGFRA.
Database reference values and therapeutic-agent listings for each molecular target
At least one computer database comprises a reference value for each of the plurality of molecular targets and a listing of available therapeutic agents for each of the plurality of molecular targets.
Comparing molecular profile test values to corresponding reference values
Computer-readable program code inputs the molecular profile test values and compares each molecular profile test value with a corresponding reference value from the at least one computer database.
Identifying therapeutic agents based on comparison indicating likely benefit
Computer-readable program code accesses the at least one computer database and identifies at least one therapeutic agent from the listing of available therapeutic agents for the plurality of molecular targets wherein the comparison to the reference values indicates a likely benefit of the at least one therapeutic agent.
Generating a report listing likely-benefit targets and identified therapeutic agents
Computer-readable program code generates a report comprising a listing of the molecular targets for which the comparison to the reference value indicated a likely benefit of the at least one therapeutic agent and the at least one therapeutic agent identified.
Overall, the claim coverage ties together molecular profiling for the specified set of targets, database-stored reference values and therapeutic-agent listings, programmatic comparison to determine likely benefit, and report generation listing targets and therapeutic agents.
Stated Advantages
Documented Applications
No documented applications found
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