Ventilation circuit adaptor and proximal aerosol delivery system
Inventors
Mazela, Jan • Henderson, Christopher
Assignees
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Publication Number
US-9352114-B2
Publication Date
2016-05-31
Expiration Date
Abstract
An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.
Core Innovation
The invention relates to a ventilation circuit adaptor for providing ventilation gas and aerosol, the adaptor having an aerosol flowpath and a ventilation gas flowpath. The adaptor includes an aerosol flow chamber with an aerosol flow channel and a ventilation gas flow chamber such that ventilation gas flows through an annular zone that is in fluid communication with the patient interface port while aerosol flows from an aerosol chamber inlet port through the aerosol flow channel and out the patient interface port.
The annular zone is bounded by a wall of the aerosol flow channel and a wall of the aerosol flow chamber, with the aerosol flowpath extending from the aerosol flow chamber inlet port, through the aerosol flow channel, and out the patient interface port. The adaptor is configured to reduce aerosol dilution by providing a ventilation gas flowpath that is at least partially offset from and encircles the aerosol path using the annular zone.
The invention further expands to proximal aerosol delivery systems that provide concomitant positive-pressure ventilation, including an aerosol entrainment chamber and auxiliary circuitry that diverts inspiratory ventilation gas as sheath gas to combine with the aerosolized active agent and form a propelled aerosolized active agent. The system includes a patient interface connected through the ventilation circuit adaptor, with an aerosol generator and an aerosol entrainment chamber forming the propelled aerosolized active agent for delivery to the patient interface.
Claims Coverage
The disclosed independent claims define a ventilation circuit adaptor architecture with at least two concurrent flowpaths: an aerosol flowpath through an aerosol flow channel to a patient interface port and a ventilation gas flowpath through a ventilation gas flow chamber that communicates with an annular zone associated with the patient interface. The independent claim specifies structural and fluid-communication elements that function together as a coupled aerosol/ventilation system for proximal aerosol delivery during ventilation.
Coaxial aerosol flow channel within aerosol flow chamber
An aerosol flow chamber having an aerosol flow channel disposed within the aerosol flow chamber, the aerosol flow channel having a longitudinal axis coaxial with the longitudinal axis of the aerosol flow chamber, extending from an aerosol flow channel inlet port to an aerosol flow channel outlet port, wherein the aerosol flow channel outlet port is in fluid communication with the patient interface port.
Annular zone bounded by aerosol channel wall and aerosol chamber wall
An annular zone is provided and bounded by the wall of the aerosol flow channel and the wall of the aerosol flow chamber, the annular zone being in fluid communication with the patient interface port, such that the aerosol flowpath extends from the aerosol flow chamber inlet port, through the aerosol flow channel, and out the patient interface port.
Ventilation gas flow chamber routed through aerosol flow chamber and annular zone
A ventilation gas flow chamber extending from a ventilation gas inlet port through the wall in the aerosol flow chamber, through and in fluid communication with the annular zone and the patient interface, and through the wall in the aerosol flow chamber and to a ventilation gas outlet port, such that the ventilation gas flowpath extends from the ventilation gas inlet port, and through the annular zone to the ventilation gas outlet port.
The claim coverage centers on an adaptor that integrates a coaxial aerosol flow channel inside an aerosol flow chamber with an annular zone that is bounded by the aerosol channel wall and the aerosol chamber wall, and that provides a ventilation gas flow chamber whose flowpath passes through the annular zone to the patient interface while the aerosol flowpath runs to the patient interface port.
Stated Advantages
Reduce aerosol dilution.
Documented Applications
Proximal delivery of aerosolized active agent during positive-pressure ventilation.
Use with invasive and noninvasive patient interfaces for proximal aerosol delivery concurrent with positive-pressure ventilation.
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