Substrate having an electron donating surface with metal particles comprising palladium on said surface
Inventors
Ohrlander, Mattias • Södervall, Billy
Assignees
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Publication Number
US-9339588-B2
Publication Date
2016-05-17
Expiration Date
Abstract
A substrate has an electron donating surface, and metal particles on its surface, the metal particles including palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of the metal particles is from about 0.001 to about 8 μg/cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ECG electrodes, peripheral stents, bone replacing implants, orthopaedic implants, orthopaedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels.
Core Innovation
The invention describes a device comprising a substrate having an electron donating surface, with metal particles deposited on an electron donating material. The metal particles comprise palladium and at least one metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum, and the amount of the metal particles is from 0.001 to about 8 μg/cm2.
The device is configured so that the metal particles deposited on the electron donating material are spaced apart so that the electron donating material is accessible from above the metal particles. The electron donating surface can be provided by the substrate or by a deposited electron-donating layer, such as Ag or Cu or Zn.
The disclosed applications relate to controlling and affecting surface interactions with biological and relevant chemical species, including hydrophobicity/contact angle, protein adsorption including fibrinogen, bacterial adhesion and growth, complement activation, platelet adhesion, immune responses, friction, tissue ingrowth, hardness, and bacterial growth prevention.
Claims Coverage
The provided claim set includes one independent claim describing the core device structure, with multiple dependent claims refining composition, particle characteristics, electron-donating materials, and interaction with biological species. The main inventive features are the specified electron-donating surface with palladium-containing metal particles, a defined metal loading range, and spaced particle deposition to keep the electron-donating material accessible from above.
Palladium-containing metal particles on an electron donating surface
A device comprising a substrate having an electron donating surface, wherein metal particles are deposited on an electron donating material, said metal particles comprising palladium and at least one metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum.
Defined metal particle loading range
A device wherein the amount of said metal particles is from 0.001 to about 8 μg/cm2.
Spaced metal particles to access electron donating material from above
A device wherein the metal particles deposited on the electron donating material are spaced apart so that the electron donating material is accessible from above the metal particles.
Across the independent claim, the coverage centers on a substrate with an electron donating surface supporting deposited palladium-containing metal particles with at least one specified additional metal at a defined loading range, while spacing the particles to keep the underlying electron donating material accessible from above. Dependent claims further specify selected electron-donating materials, quantitative refinements to loading and particle size, and interaction-focused refinements involving proteins and modification of protein adsorption.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Coated medical and life-science devices including contact lenses, pacemakers including pacemaker electrodes, stents, implants, catheters, rupture nets or mesh, dental implants, dialysis and plasmapheresis equipment, ECG electrodes, wound dressings, blood centrifuge equipment, gloves, blood bags, artificial heart valves, central and peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, and related vascular and tissue replacement devices.
Modification and tuning of surface properties including hydrophobicity/contact angle, protein adsorption including fibrinogen, bacterial adhesion and growth, and bacterial growth prevention.
Influencing immune and blood-interaction responses including complement activation, soluble complement factor C3a, and platelet adhesion.
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