Method of dose controlled application of bone graft materials by weight

Inventors

Bagga, Charanpreet S. • Bae, Hyun W.

Assignees

Prosidyan Inc

Abstract

Methods of providing dose controlled application of bone graft materials are disclosed. In particular, methods for determining a target quantity of bone graft material for clinical application in order to ensure maximum clinical results are provided. These methods comprise determining the target weight of the material to be applied.

Core Innovation

The invention provides a method of preparing a graft implant using a compressible or expandable, porous graft material. A density value of the graft material is determined, and a target porosity value for the graft implant is determined based on a clinical evaluation of a defect to be treated. A target bulk weight for a quantity of graft material to be used is calculated based on the determined density value and the target porosity value, and the graft implant is formed with the quantity of graft material representing the calculated target bulk weight.

The invention addresses dose control for graft materials by tying the implant quantity to defect-specific target porosity derived from the clinical evaluation. The calculation uses the graft material density and the target porosity value to determine the target bulk weight, including embodiments where calculating the target bulk weight further includes determining a percentage value of the volume occupied by the material. The defect is evaluated using physical parameters that may include one or more of dimension, size, geometry, volume, surface area, anatomic location, or extent of damage.

In treatment embodiments, the method includes determining the target porosity value for the graft implant based on the clinical evaluation of the defect, determining a density value of the graft material, calculating a target bulk weight, forming the graft implant with the quantity of material representing the target bulk weight calculated, and introducing the formed implant into the defect. The described graft materials include bioactive glass fibers, particles, granules, dusters, or combinations thereof, and embodiments include treating a bone defect using bone graft material.

Claims Coverage

The patent contains three independent claims, each centered on dose-controlled graft implant preparation or provision by using a target porosity derived from a clinical evaluation of a defect and calculating a target bulk weight from graft density and target porosity, with optional percentage volume-occupied formulation. Additional inventive features specify formation and/or introduction of the implant and providing sterile container dosing by weight.

Across the independent claims, the inventive concept is dose control of porous compressible or expandable graft materials by determining a target porosity from a clinical evaluation of the defect, determining graft material density, calculating a target bulk weight from density and target porosity, and using that quantity either to form an implant for introduction into the defect or to provide the graft quantity by weight in a sterile container.

Stated Advantages

Documented Applications