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Publication Number
US-9314488-B2
Publication Date
2016-04-19
Expiration Date
Abstract
The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. The agents include compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.
Core Innovation
The described invention uses cellular/egg extracts, in particular a salmon egg cellular extract, formulated in a pharmaceutically acceptable carrier, and applied to a wound so that a parameter of wound healing is improved. The disclosed extract comprises fish egg protein and an osmolarity within specified ranges, and the application is carried out under conditions that improve wound-healing outcomes.
The disclosed approach is directed to improvement of wound-healing parameters selected from speedier healing, increased scar tissue organization, less visible scar tissue thickness, lower epidermal thickness, and lower dermal thickness. The document further characterizes contemplated embodiments in which the egg extract includes nucleic acids, polypeptides, lipids, proteins, carbohydrates, and other components relevant to wound healing and scar management.
The document also describes topical formulations and delivery modes in pharmaceutically acceptable forms such as gels, creams, sprays, and wound dressings or films. It further discusses extract preparation and fractionation concepts for cytoplasmic extracts and describes phase-specific effects associated with wound healing, including collagen gene/protein production and fibroblast proliferation, along with contemplated modulation of gene expression.
Claims Coverage
The relevant material includes one independent claim describing a method of improving wound-healing parameters by topical application of a salmon egg cellular extract in a pharmaceutically acceptable carrier. The independent claim is supported by dependent claims that refine the formulation, extract type, dosage-form choices, and component selections.
Applying a salmon egg cellular extract formulation to improve a wound-healing parameter
A method of improving a parameter of wound healing in a subject by applying a formulation containing a salmon egg cellular extract formulated in a pharmaceutically acceptable carrier, wherein the cellular extract comprises about 180 to 260 mg/ml fish egg protein and an osmolarity of from about 330 to 440 mOsm, to a wound under conditions such that a parameter of wound healing is improved, the parameter being selected from speedier healing, increased scar tissue organization, less visible scar tissue thickness, lower epidermal thickness, and lower dermal thickness, and combinations thereof.
Parameter selection for wound healing and scar tissue outcomes
The method defines wound-healing improvement parameters as a selection among speedier healing, increased scar tissue organization, less visible scar tissue thickness, lower epidermal thickness, lower dermal thickness, and combinations thereof.
Topical wound-treatment composition in a pharmaceutically acceptable carrier
The method applies a formulation containing the salmon egg cellular extract formulated in a pharmaceutically acceptable carrier to a wound of the subject under conditions that improve the selected wound-healing parameter.
Across the independent claim, the inventive focus is the topical application of a salmon egg cellular extract formulation in specified ranges (fish egg protein and osmolarity) to improve defined wound-healing parameters, particularly outcomes related to speed of healing, scar tissue organization, visible scar thickness, and epidermal and dermal thickness.
Stated Advantages
Speedier healing.
Increased scar tissue organization.
Less visible scar tissue thickness.
Lower epidermal thickness.
Lower dermal thickness.
Documented Applications
Application to a wound in a subject to improve parameters of wound healing, including scar tissue outcomes and epidermal/dermal thickness.
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