Drug-eluting medical implants
Inventors
Palasis, Maria • You, Changcheng • Concagh, Danny • Core, Lee • Ho, Kicherl • Sharma, Upma • Zugates, Gregory
Assignees
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Publication Number
US-9265633-B2
Publication Date
2016-02-23
Expiration Date
Abstract
Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
Core Innovation
The document describes low-profile, self-expanding tubular medical implants formed from polymeric strands with open spaces between adjacent strands. The implant includes conformal coating layers, with a paclitaxel-containing polymer coating that provides paclitaxel as the single therapeutic agent. The claims describe implant configurations using woven polymeric strands and specify features relating to strand dimensions, tubular-structure surface area, and paclitaxel loading.
The summary reports that a conformal support coating improves radial strength and permits substantial diameter recovery after crimping. It also describes paclitaxel release over time and reports patent vessels and no device-related adverse events in a sheep peripheral artery study. The background section is not included in the provided content, so the problem being solved is not explicitly described in patent.
Claims Coverage
The three independent claims are claims 1, 14, and 20. They cover three inventive features: a coated polymer-strand tubular implant with paclitaxel, a coated implant defined by surface-area characteristics and paclitaxel loading, and a woven polymer-strand implant with a paclitaxel-containing conformal coating.
Layered conformal coatings on a polymer-strand tubular implant
Claim 1 recites a tubular structure comprising polymeric strands and open spaces between adjacent strands, a first conformal coating at least partially coating the strands, and a second conformal coating at least partially coating the first coating. The second coating comprises a second polymeric material and paclitaxel as the single therapeutic agent; the claim also specifies strand-diameter and paclitaxel-loading ranges.
Tubular implant defined by surface area and paclitaxel loading
Claim 14 recites a polymer-strand tubular structure with open spaces between adjacent strands, a first conformal coating at least partially coating the strands, and a second conformal coating at least partially coating the first coating. The second coating comprises a second polymeric material and paclitaxel as the single therapeutic agent; the claim specifies paclitaxel loading and tubular-structure surface-area ranges.
Woven polymer-strand tubular implant with a paclitaxel coating
Claim 20 recites a tubular structure formed from woven polymeric strands and a conformal coating that at least partially coats the strands and comprises paclitaxel as the single therapeutic agent. The claim also specifies strand-diameter, tubular-structure surface-area, and paclitaxel-loading ranges.
The independent claims cover layered and single-coating configurations of polymer-strand tubular medical implants containing paclitaxel as the single therapeutic agent. They distinguish the implant configurations through strand structure, coating arrangement, and surface-area and paclitaxel-loading characteristics.
Stated Advantages
The support coating is reported to improve radial strength and enable substantial diameter recovery after crimping.
Documented Applications
The document describes self-expanding tubular medical implants and reports a sheep peripheral artery study of an implant.
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