Reactor systems
Inventors
Knight, Cameron • Jones, Todd • Cole, Brady • Kubera, Paul • Donovan, Cindy L.
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-9228165-B2
Publication Date
2016-01-05
Expiration Date
Abstract
This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.
Core Innovation
The reactor system comprises a holder with an interior for removably receiving and securing a mobile carriage assembly. The holder has a receiving implement comprising at least one wheel or track and a door. The carriage assembly has primary mobility implements for moving it before insertion, secondary mobility implements for insertion into and removal from the holder, and a shaft and impellar assembly.
A disposable reaction container is removably attached to the mobile carriage assembly and encloses the shaft and impellar assembly. Its interior chamber allows reaction components to be reacted with one another, while the container separates the reaction components from the external environment. The container can be discarded after use, reducing equipment cleaning and re-sterilization.
Claims Coverage
The relevant claims identify one independent claim and three main inventive features covering the holder, mobile carriage assembly, and disposable reaction container.
Holder for receiving and securing the mobile carriage assembly
The holder comprises an interior into which the mobile carriage assembly may be removably inserted, a receiving implement comprising at least one wheel or track, and a door for securing the assembly within the holder following insertion.
Mobile carriage assembly with primary and secondary mobility implements
The assembly comprises primary mobility implements for moving it prior to insertion into the holder and secondary mobility implements for insertion into and removal from the holder using the holder’s receiving implement. It also comprises a shaft and impellar assembly.
Removable disposable reaction container
The container is removably attached to the mobile carriage assembly, comprises an interior chamber in which reaction components may be reacted with one another, encloses the shaft and impellar assembly, and separates the reaction components from the external environment.
The independent claim covers a reactor system that combines a receiving and securing holder, a mobile carriage assembly configured for movement into and out of the holder, and a disposable reaction container that encloses the shaft and impellar assembly and separates reaction components from the external environment.
Stated Advantages
The disposable reaction container can be discarded after use, reducing equipment cleaning and re-sterilization.
The reaction container separates reaction components from the external environment.
Documented Applications
The reactor system is described for chemical, pharmaceutical, and biological production.
Biological processes include microbiological culture, mammalian cell culture, and plant cell culture.
The reaction may be a step in producing a composition comprising a peptide, protein, nucleic acid, a complex thereof, or a combination thereof.
Interested in licensing this patent?