Methods, systems, and devices for monitoring anisocoria and asymmetry of pupillary reaction to stimulus
Inventors
Siminou, III, Kamran • Privitera, Claudio
Assignees
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Publication Number
US-9198570-B2
Publication Date
2015-12-01
Expiration Date
Abstract
A computer program is disclosed for performing the following method: recording images of a response of a left pupil to a stimulus thereby resulting in a first set of sequential images; recording images of a response of a right pupil to the same stimulus at the same time as the first images were recorded, thereby resulting in a second set of sequential images; displaying on a display simultaneously the first set of images and the second set of image, wherein the two sets of images are synchronized, and wherein a center of the left pupil of each image from the first set of sequential images is aligned with a center of the right pupil from the second set of sequential images on the display.
Core Innovation
The invention provides a pupillometer/pupil monitoring system implemented with a microprocessor that executes computer-executable instructions to detect anisocoria and asymmetry of pupillary reaction by recording sequential image frames of a left pupil responding to a first flash of light and a right pupil responding to a second flash of light. The left-pupil images and right-pupil images form first and second sets of sequential image frames, respectively, from imaging of the pupillary responses.
The system displays, on a display, the first set of image frames and the second set of image frames simultaneously. The two sets of image frames are synchronized per frame on the display, starting from the first frame, while a center of the left pupil of each image from the first set is aligned with a center of the right pupil of the second set on the display to enable real-time left-right comparison.
The image processing includes detecting pupil perimeters, determining pupil centers, and overlaying alignment guides on the displayed images. The guides include a line through the two pupil centers and a pair of parallel lines between the left and right pupil perimeters, with section-dependent spacing defined based on left vs right pupil diameters, and the parallel-line colors can be differentiated to emphasize differences between the left and right pupils.
Claims Coverage
The partial content identifies one independent claim (clm-00001). Dependent claim refinements add annotation and visual emphasis to the synchronized, aligned simultaneous display.
Simultaneous per-frame synchronized left and right pupil image sets with aligned pupil centers
Recording images of a left pupil responding to a first flash of light at a predetermined intensity and duration to produce a first set of sequential image frames; recording images of a right pupil responding to a second flash of light at the predetermined intensity and duration to produce a second set of sequential image frames; displaying simultaneously the first set and the second set on a display, where the first and second flashes occur at different times, the two sets are synchronized per frame on the display, and a center of the left pupil in each image from the first set is aligned with a center of the right pupil in each image from the second set on the display.
Parallel-line alignment guides with section-dependent spacing based on pupil diameters
Generating a pair of parallel lines between the left pupil perimeter and the right pupil perimeter in each image, with spacing in a first section defined by the left pupil diameter and spacing in a second section defined by the right pupil diameter.
Different colors for parallel-line guides in different sections
Making the color of the parallel lines different between the first section and the second section.
Overall claim coverage centers on simultaneous display of left- and right-pupil image sequences that are per-frame synchronized despite flashes occurring at different times, with aligned pupil centers, and perimeter-based alignment annotations via parallel guide lines, including section-dependent spacing by left versus right pupil diameters and different colors.
Stated Advantages
Aids real-time comparison of left-right pupil differences by simultaneously displaying per-frame synchronized image frames with aligned pupil centers.
Emphasizes differences between left and right pupils using alignment guides including a line through centers and a pair of parallel lines with visual differentiation.
Documented Applications
Diagnosing anisocoria and asymmetry of pupillary reaction using a pupillometer/pupil monitoring system with synchronized, aligned left and right pupil image display.
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