Detection and monitoring using high frequency electrogram analysis
Inventors
Ben-David, Tamir • Granot, Yair • Beker, Amir
Assignees
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Publication Number
US-9167980-B2
Publication Date
2015-10-27
Expiration Date
Abstract
A method for analyzing a high frequency (HF) electrogram signal including (a) providing at least one electrogram signal from an electrode located within a subject's body, (b) measuring the electrogram signal at a high frequency during a specific segment of a cardiac cycle, generating a HF electrogram signal, and (c) having a computer measure at least one time-varying parameter of the HF electrogram signal. Related apparatus and methods are also described.
Core Innovation
The invention relates to an IPG apparatus for analyzing a high frequency (HF) electrogram signal inside a living body. An electrode is provided for use inside the body, and a signal pickup picks up an electrogram signal comprising an HF component. The signal pickup, measurement unit, and analyzer are comprised within an implantable container.
The measurement unit measures the HF component from the electrogram signal only during less than 40% of a cardiac cycle. The analyzer is configured to analyze the HF component of the electrogram signal and to measure at least one time-varying parameter of the HF electrogram signal, so that the analyzer operates on an HF component acquired during a selected portion of the cardiac-cycle timing.
The time-varying parameter can include HF-derived metrics such as RMS level and measures derived from an envelope, including width and area. The document also describes time-varying parameters related to a reduced amplitude zone (RAZ) from the HF electrogram signal and/or the envelope, and it detects changes relative to a baseline to support alert generation.
The HF measurement timing can be further constrained to selected cardiac-cycle segments and/or breathing-cycle segments. The document also describes multi-location HF parameter comparison using different electrode locations, including intracoronary proximal versus distal locations near a suspected occlusion, and optionally combining HF indices with fractional flow reserve (FFR) for assessment associated with stent therapy and revascularization.
Claims Coverage
The relevant partial content identifies one independent claim (clm-00001). This claim includes 2 principal inventive elements: restricted HF-component measurement to less than 40% of the cardiac cycle, and analyzer functionality to measure at least one time-varying parameter of the HF electrogram signal within an implantable container.
Implantable hf electrogram analysis apparatus with limited cardiac-cycle measurement
An implantable pulse generator (IPG) apparatus having an electrode for use inside a living body, a signal pickup configured to pick up an electrogram signal comprising a high frequency (HF) component, a measurement unit for measuring the HF component from the electrogram signal only during less than 40% of a cardiac cycle, and an analyzer configured to analyze the HF component and to measure at least one time-varying parameter of the HF electrogram signal, wherein the signal pickup, the measurement unit and the analyzer are comprised within an implantable container.
The independent claim defines an IPG apparatus that measures an HF electrogram component only during less than 40% of a cardiac cycle and analyzes that HF component by measuring at least one time-varying parameter within the implantable container.
Stated Advantages
Improves power use by measuring the HF component only during less than 40% of a cardiac cycle.
Improves comparability by limiting HF measurement to specific cardiac-cycle segment timing and/or breathing-cycle segment timing.
Documented Applications
Detecting myocardial ischemia by analyzing HF electrogram components measured by electrodes located within the body, including intracardiac/epicardial/coronary positions, with alerts based on changes relative to a baseline.
Supporting detection of onset of atrial fibrillation by analyzing HF-derived time-varying parameters and generating alerts.
Differentiating VT vs SVT using HF electrogram time-varying parameter analysis.
Assessing coronary artery occlusion using proximal versus distal intracoronary HF parameter comparisons near a suspected occlusion.
Assessing stent therapy and revascularization by optionally combining HF indices with fractional flow reserve (FFR).
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