Drug eluting medical implant
Inventors
Palasis, Maria • You, Changcheng • Concagh, Danny • Core, Lee • Ho, Kicherl • Sharma, Upma • Zugates, Gregory T.
Assignees
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Publication Number
US-9155638-B2
Publication Date
2015-10-13
Expiration Date
Abstract
Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
Core Innovation
The described invention is a medical implant comprising a tubular structure and three conformal coatings. The first coating comprises poly(lactic acid-co-caprolactone) and increases the mass of the tubular structure by at least about 20 percent. A second coating at least partially coats the first coating and comprises a second polymeric material and paclitaxel, while a third coating at least partially coats the second coating and comprises a third polymeric material.
The description states that the PLCL coating improves post-crimp diameter recovery to at least about 90%, and that examples report tunable mechanical forces and drug release over time. The described implant is associated with lumen applications, including vascular treatment. The background section is not included in the provided content, so the problem identified in that section is not explicitly described.
Claims Coverage
The provided claims identify two inventive features across independent claims 1 and 13. Both cover a medical implant with a tubular structure and three conformal coatings, differing in how the paclitaxel amount in the second coating is specified.
Implant with paclitaxel weight-percentage range
Claim 1 recites a tubular structure comprising a first polymeric material; a first conformal coating comprising poly(lactic acid-co-caprolactone), at least partially coating the tubular structure and increasing its mass by at least about 20 percent; a second conformal coating comprising a second polymeric material and between 0.3 weight percent and 5 weight percent paclitaxel; and a third conformal coating comprising a third polymeric material.
Implant with paclitaxel amount per tubular-structure length
Claim 13 recites a tubular structure comprising a first polymeric material; a first conformal coating comprising poly(lactic acid-co-caprolactone), at least partially coating the tubular structure and increasing its mass by at least about 20 percent; a second conformal coating comprising a second polymeric material and between 2.5 micrograms and 20 micrograms of paclitaxel per 10 millimeters of tubular-structure length; and a third conformal coating comprising a third polymeric material.
The two independent claims cover the same general arrangement of a polymeric tubular structure and three conformal coatings. They distinguish the paclitaxel-containing second coating by specifying either a weight-percentage range or an amount per length of the tubular structure.
Stated Advantages
The PLCL coating improves post-crimp diameter recovery to at least about 90%.
Documented Applications
Use in lumen applications, including vascular treatment.
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