Methods of treating drug side-effects that include a gastrointestinal spasm

Inventors

Huang, Alexander L • Wu, Gin

Assignees

LiveLeaf Inc

Abstract

Methods of treating drug side-effects including gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.

Core Innovation

The invention relates to methods of inhibiting the onset of, and treating, a gastrointestinal spasm associated with drug side-effects in a subject by administering an effective amount of a composition. The composition includes a water soluble tannin or a water soluble polyphenol comprising a tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient, with the tannin or polyphenol having a molecular weight ranging from about 170 Daltons to about 4000 Daltons.

In related embodiments, the composition is produced by combining a water soluble tannin with hydrogen peroxide at a tannin:peroxide weight ratio ranging from about 1:1000 to about 10:1, removing free hydrogen peroxide from the combination, and mixing the combination with a pharmaceutically acceptable excipient to create the formulation. Other embodiments specify a water-soluble polyphenol water-extracted from pomegranate husk and green tea leaf and combined with hydrogen peroxide prior to administering.

Further embodiments specify hydrogen peroxide concentration ranging from about 0.001% to about 2.0% based on total dry weight of the composition. Other embodiments extract a water soluble polyphenol from a combination of green tea leaf and pomegranate husk, combine the polyphenol with hydrogen peroxide prior to administering, select a desired concentration, and dilute to the desired concentration before administering.

Claims Coverage

The independent claims are directed to methods for inhibiting the onset of, and treating, a gastrointestinal spasm associated with drug side-effects by administering an effective amount of a tannin or tannin-containing polyphenol-hydrogen peroxide composition. Across the independent claims, the inventive features focus on the composition, the defined molecular weight range, the tannin:peroxide weight ratio or hydrogen peroxide concentration, and, in some claims, removal of free hydrogen peroxide or extraction from pomegranate husk and green tea leaf.

Across the independent claims, the claimed methods rely on administering an effective amount of a composition combining a water soluble tannin or tannin-containing water soluble polyphenol with hydrogen peroxide, with defined molecular weight ranges and tannin:peroxide weight ratio or hydrogen peroxide concentration. Some claims further limit preparation by removing free hydrogen peroxide or by extracting polyphenols or tannins from pomegranate husk and green tea leaf.

Stated Advantages

Documented Applications