Wound care products with peracid compositions
Inventors
Neas, Edwin D. • HANDLEY, Michael K. • Marchitto, Kevin S. • Flock, Stephen T.
Assignees
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Publication Number
US-9044527-B2
Publication Date
2015-06-02
Expiration Date
Abstract
Methods have been developed for incorporation of a peracid compound into or on wound application matrices, such as bandages or dressings, and other matrices which will favorably impact wound healing and help eliminate microbial infection. The peracid compound comprises a base compound that is metabolically pertinent to wound healing, the oxidized form of the base compound (a peracid), and an appropriate oxidizer, such as hydrogen peroxide. In addition, other excipients with wound healing potential, such as esters of the base compound, may be added to the peracid compound. The combination peracid-wound application matrices can be used to disinfect and heal various wound types with designed time release of the peracid compound.
Core Innovation
A wound treating matrix is provided that includes at least one layer that is non-aqueous. The non-aqueous layer comprises an antimicrobial composition that includes a carboxylic acid, the peracid of the carboxylic acid, the ester of the carboxylic acid, and an oxidizer in a non-aqueous medium.
The wound treating matrix addresses problems associated with peracid antimicrobial compositions in wound environments by stabilizing peracids in non-aqueous media. The matrix enables time release and controlled delivery of the antimicrobial composition upon contact with wound moisture, and provides permeation and diffusion control using membranes or barriers.
The disclosure also describes wound treating matrices such as non-aqueous layers, films, hydrogels, and multi-layer dressings that incorporate these peracid-containing antimicrobial compositions. Further implementations include peracid binding or impregnation on polymeric or solid scaffolds, and an aqueous-layer separation scheme in which the aqueous layer is kept separate from a non-aqueous layer before use.
Claims Coverage
The independent claim covers a wound treating matrix with at least one non-aqueous layer containing a specific antimicrobial composition, with multiple refinements addressing layer separation, release or migration on water contact, peracid class, peracid bonding, and structural backing layers. Six inventive features are identified from the provided claim excerpts.
Non-aqueous wound treating matrix with carboxylic acid/peracid/ester plus oxidizer
A wound treating matrix comprising at least one layer which is non-aqueous that comprises an antimicrobial composition comprising a carboxylic acid, the peracid of said carboxylic acid, the ester of said carboxylic acid, and an oxidizer in a non-aqueous medium.
Aqueous-layer separation with antimicrobial migration
A wound treating matrix that includes an aqueous layer, where the aqueous layer is kept separate from a non-aqueous layer before use, and during use the non-aqueous layer contacts the aqueous layer so an antimicrobial composition migrates into the aqueous layer.
Release upon contact with water-based fluid
The wound treating matrix releases an antimicrobial composition from a non-aqueous layer upon contact with a water-based fluid.
Peracid as a peroxy alpha-ketocarboxylic acid
The wound treating matrix uses a peracid that is a peroxy α-ketocarboxylic acid.
Peracid chemically bonded to a polymer in the non-aqueous layer
The wound treating matrix includes a non-aqueous layer comprising a polymer to which the peracid is chemically bonded.
Non-aqueous layer with a liquid-impermeable backing layer
The wound treating matrix further includes a liquid-impermeable backing layer adjacent to the non-aqueous layer.
Overall, the claim set is centered on a wound treating matrix with a non-aqueous antimicrobial composition containing a carboxylic acid, its peracid, its ester, and an oxidizer, refined by features governing separation between aqueous and non-aqueous layers, release or migration upon water contact, restriction to peroxy α-ketocarboxylic acids, optional chemical bonding of the peracid to a polymer, and a liquid-impermeable backing layer adjacent to the non-aqueous layer.
Stated Advantages
Stabilizes peracid antimicrobial compositions in non-aqueous media.
Enables time release and controlled delivery upon contact with wound moisture.
Provides permeation and diffusion control using membranes or barriers.
Maintains antimicrobial activity, including retention of peracid activity after extended storage.
Provides antibacterial inhibition associated with MRSA in the described examples.
Documented Applications
Wound treating matrices for antimicrobial treatment of wounds, including wound coverings, dressings, and bandages that incorporate peracid antimicrobial compositions.
MRSA inhibition in the context of peracid-containing wound treating matrices, as shown by inhibition assays described in the disclosure.
Controlled permeation and diffusion through hydrogels and barrier or membrane arrangements in wound treating matrices.
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