Phenyl carbamate compounds for use in preventing or treating stroke
Inventors
Assignees
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Publication Number
US-9034848-B2
Publication Date
2015-05-19
Expiration Date
Abstract
A phenyl carbamate compound; a composition for treating and/or preventing stroke containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or preventing stroke comprising administering the phenyl carbamate compound or a pharmaceutically acceptable salt thereof to a patient in need of stroke treatment; and a use of the phenyl carbamate compound or a pharmaceutically acceptable salt thereof in treating and/or preventing stroke, are provided.
Core Innovation
The invention relates to phenyl carbamate compounds represented by Chemical Formula 1, including pharmaceutically acceptable salts and stereochemical forms such as racemate, enantiomer, diastereomer, and mixtures. Chemical Formula 1 defines X as a halogen, n as an integer from 1 to 5, R1 as a linear or branched alkyl group of C1-C4, and R2 and R3 as independently selected from hydrogen, linear or branched C1-C4 alkyl, C3-C8 cycloalkyl, or benzyl.
A is defined as hydrogen or a carbamoyl derivative, and B is defined as hydrogen, a carbamoyl derivative, trialkyl silyl groups, trialkylaryl silyl groups, or a trialkyl silyl ether group. A and B are not carbamoyl derivatives at the same time. The document also includes phenyl hydroxyalkyl carbamate derivatives and N-substituted carbamates within the Chemical Formula 1 scope.
The invention provides a method of treating stroke by administering a pharmaceutically effective amount of a phenyl carbamate compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof to a subject in need thereof. The target conditions are ischemic stroke and hemorrhagic stroke, and the document asserts a remarkably excellent anti-stroke effect and very low toxicity.
Claims Coverage
The claim set includes one independent claim directed to treating stroke by administering a pharmaceutically effective amount of a phenyl carbamate compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt. The inventive scope centers on the defined compound framework and substituent constraints, with dependent claims refining specific compound selections, stereochemical forms, and stroke type.
Treating stroke with a Chemical Formula 1 phenyl carbamate
A method of treating stroke by administering a pharmaceutically effective amount of a phenyl carbamate compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof to a subject in need thereof.
Defined substituent framework for Chemical Formula 1
X is a halogen, n is an integer from 1 to 5, R1 is a linear or branched alkyl group of C1-C4, and R2 and R3 are independently selected from hydrogen, linear or branched alkyl groups of C1-C4, cycloalkyl groups of C3-C8, and benzyl group.
Non-simultaneous carbamoyl substitution on A and B
A is hydrogen or a carbamoyl derivative, B is hydrogen, a carbamoyl derivative, trialkyl silyl groups, trialkylaryl silyl groups, or a trialkyl silyl ether group, and A and B are not carbamoyl derivatives at the same time.
Dependent narrowing to specific compound forms and stroke types
Dependent claims refine the administered compound to enumerated phenyl carbamate derivatives, specific stereochemical forms such as racemate, enantiomer, diastereomer, or mixtures, and ischemic stroke or hemorrhagic stroke.
Overall, the claims cover stroke treatment by administering Chemical Formula 1 phenyl carbamate compounds or salts with defined halogen, alkyl, carbamoyl-related, and R2/R3 substituent limits, including the requirement that A and B are not carbamoyl derivatives at the same time. Dependent claims further narrow the scope to particular phenyl carbamate derivatives, stereochemical forms, and ischemic or hemorrhagic stroke.
Stated Advantages
Remarkably excellent anti-stroke effect.
Very low toxicity.
Documented Applications
Treatment of stroke by administering a phenyl carbamate compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof.
Treatment of ischemic stroke or hemorrhagic stroke.
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