Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration
Inventors
Assignees
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Publication Number
US-8999972-B2
Publication Date
2015-04-07
Expiration Date
Abstract
The present invention provides methods and compositions comprising compounds useful for stimulating neurogenesis. The methods and compositions comprising compounds are also useful for inhibiting neuronal degeneration. Thus, the present invention can be used in the treatment of diseases and conditions characterized by neuronal loss and reduced neurogenesis including Alzheimer's disease, stroke, traumatic brain injury, and depression. This invention could also be used for research products including single agents or mixtures of agents to promote, proliferate, differentiate, or maintain neurons from stem or progenitor cells.
Core Innovation
The invention relates to methods for stimulating neurogenesis and inhibiting neuronal degeneration in a mammal by administering a pharmaceutical composition in an amount effective to stimulate neurogenesis and/or inhibit neuronal degeneration. The pharmaceutical composition comprises a compound selected from a group consisting of compounds represented by formulas I-XV and a pharmaceutically-acceptable carrier.
The invention addresses neuronal loss, including neuronal degeneration associated with neurodegenerative diseases and neuropsychiatric disorders. The document identifies Alzheimer’s disease, stroke, traumatic brain injury, depression, and aging as conditions described in the provided content, and provides pharmaceutical compositions and methods of use for stimulating neurogenesis and inhibiting neuronal degeneration in a mammal.
The compositions include salt forms and stereoisomers, and additional embodiments describe formulation options such as unit-dose and multi-dose containers, sterile isotonic injection solutions/suspensions, lyophilized formulations, injectable liquid carriers, and kit formats.
Claims Coverage
The independent claims cover two method forms for stimulating neurogenesis and inhibiting neuronal degeneration in a mammal. Together they present two inventive feature sets based on administration of a pharmaceutical composition in an effective amount, with a pharmaceutically-acceptable carrier, using either a group-selected compound or a formula-defined compound.
Effective administration to stimulate neurogenesis and inhibit neuronal degeneration
A method for stimulating neurogenesis and inhibiting neuronal degeneration in a mammal by administering a pharmaceutical composition in an amount effective to stimulate neurogenesis and/or inhibit neuronal degeneration, the composition comprising a compound selected from a group and a pharmaceutically-acceptable carrier.
Administration of formula-defined compound to stimulate neurogenesis and inhibit neuronal degeneration
A method for stimulating neurogenesis and inhibiting neuronal degeneration in a mammal by administering a pharmaceutical composition comprising a compound of a formula with variable substituents, together with a pharmaceutically acceptable carrier in an amount effective to stimulate neurogenesis and/or inhibit neuronal degeneration in the mammal.
Claim coverage centers on administering an effective amount of a pharmaceutical composition containing either a group-selected compound or a formula-defined compound, together with a pharmaceutically acceptable carrier, to stimulate neurogenesis and/or inhibit neuronal degeneration.
Stated Advantages
Stated therapeutic utility for stimulating neurogenesis and inhibiting neuronal degeneration.
Treatment of neurodegenerative diseases, psychiatric disorders, and aging as described in the provided content.
Documented Applications
Treatment of neurodegenerative diseases including Alzheimer’s disease, stroke, and traumatic brain injury by stimulating neurogenesis and inhibiting neuronal degeneration.
Treatment of neuropsychiatric conditions including depression by stimulating neurogenesis and inhibiting neuronal degeneration.
Methods of use for neurogenesis stimulation and inhibition of neuronal degeneration to treat neurodegenerative diseases, psychiatric disorders, and aging as described in the provided content.
In vitro neurogenesis/neuroprotection testing using stem/progenitor cells with presented results in tables 2-5.
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