Method of inhibiting harmful microorganisms and barrier-forming composition therefor
Inventors
Sokol, Brian Vincent • Ghannoum, Afif Mahmoud
Assignees
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Publication Number
US-8992893-B2
Publication Date
2015-03-31
Expiration Date
Abstract
In an embodiment, the barrier-forming composition includes a carbohydrate gum, a humectant, and an antimicrobial agent. The composition furthermore meets the following requirements: about 0.01%≦C≦about 0.4%; about 4.5%≦H≦about 65%; and 0.050%<A; or about 0%≦C≦about 0.4%; about 55%≦H≦about 65%; and 0.050%<A. C is the carbohydrate gum; H is the humectant; and A is the antimicrobial agent. All percentages are by weight of the total composition. In an embodiment the barrier-forming composition has an Rf value in water of 0 to about 0.25.
Core Innovation
The invention relates to a barrier-forming mucosal composition comprising a carbohydrate gum, a humectant, and an antimicrobial agent. The composition is a solution in which the carbohydrate gum, the humectant, and the antimicrobial agent are present at by-weight ranges of about 0.01% to about 0.4%, about 4.5% to about 65%, and greater than 0.050%, respectively.
A related aspect is a barrier-forming composition that additionally has an Rf value in water of 0 to about 0.25. This composition includes the same carbohydrate gum, humectant, and antimicrobial agent components, with the same constraints for the carbohydrate gum and humectant by weight.
Another aspect is a method for making a mucosal barrier-forming composition by mixing and heating a carbohydrate gum, a humectant, and an antimicrobial agent to form a solution. The resulting composition meets the by-weight requirements for the carbohydrate gum, humectant, and antimicrobial agent, and when applied to a mammal mucosa provides antimicrobial cidal or static activity against airborne germs for about two hours to about six hours based on in vivo testing.
Claims Coverage
The partial content identifies three independent claims: one composition claim with carbohydrate gum, humectant, and antimicrobial agent constraints and an in vivo duration requirement; a second composition claim that further requires an Rf value in water constraint; and one method claim defined by mixing and heating to form a solution with the same concentration constraints and in vivo duration requirement. Across these independent claims, the inventive features focus on component-constrained barrier-forming mucosal compositions and their application to mammal mucosa for antimicrobial cidal or static activity against airborne germs for about two hours to about six hours based on in vivo testing.
Barrier-forming mucosal solution composition with carbohydrate gum, humectant, and antimicrobial agent constraints
A barrier-forming composition comprising a carbohydrate gum, a humectant, and an antimicrobial agent, where about 0.01% less than or equal to carbohydrate gum less than or equal to about 0.4%, about 4.5% less than or equal to humectant less than or equal to about 65%, and greater than 0.050% antimicrobial agent, the composition is a solution, and when applied to a mammal mucosa has antimicrobial cidal or static activity against airborne germs for about two hours to about six hours based on in vivo testing.
Barrier-forming mucosal solution with water Rf constraint
A barrier-forming composition comprising a carbohydrate gum, a humectant, and an antimicrobial agent, where about 0.01% less than or equal to carbohydrate gum less than or equal to about 0.4% and about 4.5% less than or equal to humectant less than or equal to about 65%, the barrier-forming composition has an Rf value in water of 0 to about 0.25, the composition is a solution, and when applied to a mammal mucosa has antimicrobial cidal or static activity against airborne germs for about two hours to about six hours based on in vivo testing.
Mixing and heating method for making a mucosal barrier-forming composition
A method for making a mucosal barrier-forming composition comprising mixing and heating a carbohydrate gum, a humectant, and an antimicrobial agent to form a solution, where about 0.01% less than or equal to carbohydrate gum less than or equal to about 0.4%, about 4.5% less than or equal to humectant less than or equal to about 65%, and greater than 0.050% antimicrobial agent, and when the composition is applied to a mammal mucosa it has antimicrobial cidal or static activity against airborne germs for about two hours to about six hours based on in vivo testing.
The independent claims collectively cover a barrier-forming mucosal solution with specified by-weight ranges for carbohydrate gum, humectant, and antimicrobial agent that provides antimicrobial cidal or static activity against airborne germs on mammal mucosa for about two to six hours based on in vivo testing; the same composition concept with an additional Rf value in water constraint of 0 to about 0.25; and a mixing-and-heating method to make such a composition that meets the same concentration constraints and the same in vivo duration requirement.
Stated Advantages
Provides antimicrobial cidal or static activity against airborne germs on mammal mucosa for about two hours to about six hours based on in vivo testing.
Documented Applications
Applying the composition to a mammal mucosa for antimicrobial cidal or static activity against airborne germs for about two hours to about six hours based on in vivo testing.
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