Device and method for drug delivery
Inventors
Pesach, Benny • Bitton, Gabriel • Nagar, Ron • Weiss, Ram
Assignees
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Publication Number
US-8961458-B2
Publication Date
2015-02-24
Expiration Date
Abstract
A therapeutic treatment device, system and method for improving administration of a temperature sensitive drug into a tissue on the body of a patient at a drug injection site are disclosed. The device includes a treatment element with a controllable heating element in temperature communicative contact with the tissue adjacent to the drug injection site. The controllable heating element is configured to heat the tissue adjacent to the drug injection site to a controllable temperature but does not heat the injected drug above a predetermined limiting temperature, above which degradation of the injected drug may occur.
Core Innovation
The invention relates to a treatment device for administering at least one injection of a drug into tissue using a treatment element having a plurality of injection sites, where each injection site corresponds to a predetermined location on the tissue for injection of the drug at a specific time. The treatment element includes a processor and a heating element provided within or adjacent to the treatment element, and the heating element is controlled by and electrically coupled to the processor to apply heat to the tissue at the predetermined location during at least one of before, during and after injection of the drug for a predetermined period of time.
The device further includes a temperature sensor electrically coupled to the processor, where the temperature sensor provides a signal corresponding to the temperature of the tissue heated by the treatment element. Based on the temperature of the tissue, the processor stabilizes heating of the tissue to a predetermined temperature that is less than a predetermined limiting temperature. The application of heat is intended to improve pharmacokinetic and/or pharmacodynamic properties of the drug.
The treatment element includes a disposable part and a reusable part, where the disposable part includes at least one identification element configured to determine whether the disposable part has been used. The disclosed approach supports managing injections across multiple injection sites and coordinating heating around injection times while maintaining temperature control to prevent heating the injected drug above the predetermined limiting temperature.
Claims Coverage
The independent claims provide two inventive features sets centered on a treatment device and a method of administering a drug. They share predetermined injection locations and times, processor-controlled heating, temperature sensing with stabilization below a limiting temperature, and a disposable part with an identification element to determine whether it has been used.
Predetermined injection sites mapped to tissue locations and times
A treatment element having a plurality of injection sites for administering at least one injection of a drug into tissue, wherein each injection site corresponds to a predetermined location on the tissue for injection of the drug at a specific time.
Processor-controlled heating element with timing relative to injection
A processor provided within the treatment element and a heating element provided within or adjacent to the treatment element, electrically coupled to the processor and configured to apply heat to the tissue at the predetermined location during at least one of before, during and after injection of the drug for a predetermined period of time such that the tissue is heated to a predetermined temperature less than a predetermined limiting temperature.
Temperature sensor for stabilizing tissue heating below a limiting temperature
A temperature sensor electrically coupled to the processor and configured to provide a signal corresponding to the temperature of the tissue heated by the treatment element, wherein based on the temperature of the tissue the processor stabilizes heating of the tissue to the predetermined temperature.
Improving pharmacokinetic and/or pharmacodynamic properties
Application of heat by the heating element is configured to improve pharmacokinetic and/or pharmacodynamic properties of the drug.
Disposable part with identification element to determine whether it has been used
The treatment element includes a disposable part and a reusable part, and the disposable part includes at least one identification element configured to determine whether the disposable part has been used.
Temperature communicative contact and temperature-based control of heating
A method that includes placing the treatment device in temperature communicative contact with tissue at the predetermined location, administering the drug at the predetermined location using a first injection site, applying the heat to the tissue at the predetermined location, determining a temperature of the tissue at the predetermined location, and controlling, based on the determined temperature, the heating of the tissue to prevent heating the injected drug above the predetermined limiting temperature.
The claims define a multi-injection treatment element that applies processor-controlled heating to predetermined tissue locations during or around injection, while a temperature sensor enables stabilization to a predetermined temperature below a limiting temperature. They also include a disposable part with an identification element to determine whether it has been used, and link heat application to improving pharmacokinetic and/or pharmacodynamic properties and preventing heating above the limiting temperature.
Stated Advantages
Improves pharmacokinetic and/or pharmacodynamic properties of the drug.
Prevents heating the injected drug above the predetermined limiting temperature.
Documented Applications
No documented applications found
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