Balanced physiological monitoring and treatment system
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Publication Number
US-8956291-B2
Publication Date
2015-02-17
Expiration Date
Abstract
A system and method for providing balanced, automated regulation of a patient's physiological condition by monitoring at least one physiological parameter and, optionally, monitoring and controlling additional physiological parameters, is disclosed. The system includes a physiological parameter monitor, an intelligent control device and a multi-channel delivery device for providing controlled intravenous delivery of at least two medications that affect the physiological condition being controlled. Control logic in the intelligent control device is derived by an algorithm based on model predictive control. The control logic includes mathematically modeled systems, empirical data systems or a combination thereof. The system of the present invention is optionally included in a networked system to provide centralized data storage and archival of system information as well as data export and query capabilities that can be used for patient file management, health care facility management and medical research.
Core Innovation
The invention provides an ICU-focused balanced physiological monitoring and control system that includes a physiological parameter monitor, an intelligent adaptive controller, and a multi-channel delivery manifold. The physiological parameter monitor monitors physiological parameters of a patient, and the control device receives and stores physiological parameter data and translates that data into an output control signal containing information regarding administration of at least two counterbalancing medications.
Adaptive control logic analyzes patient-specific sensitivity to dosage by monitoring patient responses and converting measured parameter behavior into an adaptive dosage control strategy. The system defines baseline dosage functions and expected response functions, and computes localized patient-specific sensitivity by comparing a measured rate of change in a physiological parameter to an expected rate of change in the physiological parameter.
The adaptive approach uses mathematically modeled systems and/or empirical data systems within model predictive control logic to generate patient-tailored dosages. Physiological conditions are addressed using multiple physiological parameters and counterbalancing medication pairs, including glucose/insulin, coagulation status/coagulant-anticoagulant, and vasodilator/vasoconstrictor, with optional network integration for remote monitoring, centralized data storage and archival, and data export/query for patient, file, or research management.
Claims Coverage
The document includes two independent claims, each covering an adaptive monitoring and control system and a corresponding method. Across the independent claims, the main inventive features relate to adaptive patient-specific sensitivity to dosage using localized measured-versus-expected rate-of-change analysis, and generation of an output control signal to administer at least two counterbalancing medications via a multi-channel delivery mechanism to stabilize and balance a physiological condition.
Adaptive optimization of patient-specific sensitivity to dosage using stored physiological parameter data
A control device operably connected to said physiological parameter monitor, said control device having adaptive control logic for adaptive optimization of patient-specific sensitivity to dosage by monitoring, receiving and storing physiological parameter data from said physiological parameter monitor.
Output control signal for administration of at least two counterbalancing medications
Translating said physiological parameter data into an output control signal containing information regarding administration of at least two counterbalancing medications.
Multi-channeled delivery mechanism to infuse counterbalancing medications to stabilize and balance
A multi-channeled delivery mechanism operably connected to said control device, structured to infuses said at least two counterbalancing medications into the patient based on said information contained in said output control signal to adaptively stabilize and balance said physiological parameter or physiological condition of the patient.
Localized patient-specific sensitivity from measured versus expected rate of change
Analyzing said patient-specific sensitivity by calculating a localized patient-specific sensitivity to dosage of at least one of said at least two medications, said localized patient-specific sensitivity calculated by comparing a measured rate of change in said physiological parameter to an expected rate of change in said physiological parameter.
Taken together, the independent claims cover an adaptive control architecture that optimizes patient-specific sensitivity to dosage using physiological parameter data and localized sensitivity derived from measured versus expected rate-of-change, then translates that analysis into an output control signal used to infuse at least two counterbalancing medications through a multi-channeled delivery mechanism to adaptively stabilize and balance the patient’s physiological parameter or physiological condition.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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