Tannin formulation for treating malnutrition
Inventors
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-8952072-B2
Publication Date
2015-02-10
Expiration Date
Abstract
Methods of treating malnutrition are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.
Core Innovation
The described invention relates to treating a gastrointestinal spasm associated with malnutrition in a subject by administering an effective amount of a formulation. The formulation includes a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient, and the tannin has a molecular weight ranging from about 170 Daltons to about 4000 Daltons with a tannin:peroxide weight ratio ranging from about 1:1000 to about 10:1.
The invention further encompasses a process in which the formulation is produced by combining a water soluble tannin with hydrogen peroxide at the specified tannin:peroxide weight ratio and tannin molecular weight range. The process includes removing free hydrogen peroxide from the combination and mixing the remaining combination with a pharmaceutically acceptable excipient to create the formulation.
In another claimed aspect, the invention includes concurrently administering a combination of a composition and a nutritional supplement. The composition is produced from combining a water soluble, hydrolysable tannin with hydrogen peroxide at the specified tannin:peroxide weight ratio and tannin molecular weight range, and the nutritional supplement is selected from sodium, potassium, dextrose, fructose, glucose, magnesium, zinc, selenium, Vitamin A, Vitamin D, Vitamin C, dietary fiber, and combinations thereof.
Claims Coverage
The partial content includes three independent claims. Across these claims, the inventive features center on administration of a formulation combining water soluble tannin with hydrogen peroxide in a pharmaceutically acceptable excipient, specified tannin molecular-weight and tannin:peroxide weight ratio ranges, producing the formulation by removing free hydrogen peroxide and mixing with excipient, and concurrent administration of a nutritional supplement selected from a defined group.
Water soluble tannin combined with hydrogen peroxide formulation for treating malnutrition-associated gastrointestinal spasm
Administering an effective amount of a formulation to a subject having malnutrition with an associated gastrointestinal spasm, the formulation having a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient.
Specified tannin molecular weight and tannin:peroxide weight ratio
The formulation includes a tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons, and a tannin:peroxide weight ratio ranging from about 1:1000 to about 10:1.
Producing the formulation by removing free hydrogen peroxide and mixing with excipient
Producing the formulation by combining a water soluble tannin with hydrogen peroxide at the specified tannin:peroxide weight ratio, removing free hydrogen peroxide from the combination, and mixing the remaining combination with a pharmaceutically acceptable excipient to create the formulation.
Selecting a desired concentration for administering
The administering includes selecting a desired concentration of the formulation for the administering.
Concurrently administering a composition with a nutritional supplement selected from a defined group
Concurrently administering a composition produced from combining a water soluble, hydrolysable tannin with hydrogen peroxide and a nutritional supplement selected from sodium, potassium, dextrose, fructose, glucose, magnesium, zinc, selenium, Vitamin A, Vitamin D, Vitamin C, dietary fiber, and combinations thereof.
The claims cover methods of treating malnutrition-associated gastrointestinal spasm by administering a formulation comprising water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient, with specified molecular-weight and weight-ratio ranges. The claims also cover producing the formulation by removing free hydrogen peroxide and mixing with excipient, selecting a desired concentration, and concurrently administering a nutritional supplement selected from a defined group.
Stated Advantages
Relieves the malnutrition in the subject by relieving the associated gastrointestinal spasm when compared to a control group in which the formulation was not administered.
Relieves the associated gastrointestinal spasm when compared to baseline health of the subject.
Documented Applications
Treating gastrointestinal spasms associated with malnutrition in a subject.
Relieving malnutrition-associated gastrointestinal spasm in an irritable bowel syndrome (IBS) pilot open-label study (29 patients), reporting symptom improvement/relief compared to historical baseline.
Addressing abdominal cramps and alcohol overindulgence prophylaxis as discussed in the partial content summary.
Interested in licensing this patent?