Nanostructured surfaces for biomedical/biomaterial applications and processes thereof
Inventors
Robeson, Lloyd M. • Rothrock, Ginger Denison
Assignees
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Publication Number
US-8944804-B2
Publication Date
2015-02-03
Expiration Date
Abstract
A medical device includes a textured surface having a predetermined nanostructure, wherein the nanostructure is less than about 500 nanometers in a broadest dimension. The textures nanostructure surface reduces friction between the medical device and biological tissue.
Core Innovation
The invention relates to a mold for fabricating nano-structured surfaces for medical articles. The mold has a first surface that defines nano-structures less than about 500 nm in a broadest dimension, and the mold includes a continuous layer of oligomer produced by polymerization of selected fluorinated monomers including trifluorochloroethylene, trifluoroethylene, and multiple (meth)acrylate and perfluoro(vinyl ether) monomers, with combinations thereof. The mold further includes a functional monomer included in the polymerization of the oligomer, where the functional monomer is selected from a defined group.
The system also includes such a mold in which the first surface defines nano-structures less than about 500 nm in a broadest dimension for molding nano-structures therefrom. A biomaterial is configured to be molded by the mold to form a medical article that treats a biologic tissue or condition, and the mold retains the continuous oligomer layer formed from the selected monomers and includes the functional monomer selected from the defined group.
The invention also relates to fluorinated polymer network formation using thermally cured urethane-linkage chemistries and epoxy-based chemistries, including two-component systems in which cure conditions and component ratios produce mechanically stable networks. It includes UV/thermal dual and orthogonal curing chemistry embodiments for fluorinated polymer networks, with thermally cured PU-Tetrol, PU-Triol, thermally cured epoxy, UV-cured epoxy, epoxy dual cure, orthogonal cure with triol, UV with epoxy dual cure, and orthogonal cure with diisocyanate.
Across these variants, the compositions form mechanically stable, chemically stable networks with optical clarity and adhesion performance, and representative chemical structures are provided. The document further describes optional mold features focused on surfactant inclusion for wetting characteristics, with surfactant options limited to specified surfactant types and/or specified fluorinated surfactants, including perfluorooctanoic acid and perfluorooctane sulfonic acid, and combinations thereof.
Claims Coverage
The provided independent claims are clm-00001 and clm-00007. Across these claims, the inventive coverage centers on a fluorinated continuous-oligomer mold having a first surface defining nano-structures under about 500 nm, with a functional monomer incorporated in the oligomer polymerization, and on molding a biomaterial to form a medical article that treats biologic tissue or conditions.
Fluorinated continuous-oligomer nano-structure mold with functional monomer
A mold for fabricating nano-structured surfaces for medical articles, having a first surface defining nano-structures less than about 500 nm in a broadest dimension; comprising a continuous layer of oligomer produced from polymerization of monomers selected from a defined fluorinated/perfluorinated monomer group; and including a functional monomer in the polymerization, where the functional monomer is selected from a defined group.
Molding system using the fluorinated nano-structure mold to form a treating medical article
A system for fabricating nano-structured medical articles, comprising a mold with a first surface defining nano-structures less than about 500 nm in a broadest dimension for molding nano-structures therefrom; the mold comprising a continuous layer of oligomer produced from polymerization of monomers selected from a defined fluorinated/perfluorinated monomer group; and a biomaterial configured to be molded by the mold to form a medical article that treats a biologic tissue or condition; wherein the mold further comprises a functional monomer included in the polymerization of the oligomer selected from a defined group.
Taken together, the independent claims claim a mold and system in which a first surface forms nano-structures under about 500 nm and a continuous oligomer layer is formed from specified fluorinated/perfluorinated monomers, with incorporation of a defined functional monomer to support molding a biomaterial into a medical article that treats biologic tissue or conditions.
Stated Advantages
Reducing friction between the medical device and biological tissue.
Tough mechanically stable network (PU-Tetrol embodiment).
Slightly cloudy network associated with tetrol-based immiscibility.
Clear and colorless network (PU-Triol embodiment).
High chemical stability network (thermally cured epoxy and UV-cured epoxy).
Optical clarity (clear/colorless or clear/yellow cured networks, depending on embodiment).
Strong adhesion (UV-thermal dual cure with tetrol-based system).
Very strong adhesion (orthogonal UV to thermal system).
Documented Applications
Medical articles for treating biologic tissues or conditions using nano-structured surfaces defined by molds with nano-structures less than about 500 nm.
A medical device configured to reduce friction between the medical device and biological tissue.
Medical probes/devices selected from a catheter, a surgical probe, a stent insertion probe, a drain, a tube, a cannula, and a surgical needle.
Thermally cured and UV/thermal dual/orthogonal curing chemistry embodiments for fluorinated polymer networks, including formulations that provide optical clarity and/or adhesion performance.
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