Sterilant composition and system
Inventors
Roberts, Keith Allen • Hahn, Carl William • Kern, Gabriel P. • Hoitink, Ryan A. • Crowder, Robert Orvin • Burban, John Henry
Assignees
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Publication Number
US-8920715-B2
Publication Date
2014-12-30
Expiration Date
Abstract
An antimicrobial solution for disinfecting instruments in an automatic sterilization device, the solution comprising: a peracid reaction product formed in situ from combining a liquid acetyl donor with a solid source of peroxide, wherein the in situ reaction takes place in the sterilization device, along with a containment and delivery ampule for use in an automatic sterilization device, and methods for disinfecting a medical instrument employing the inventive antibacterial solution.
Core Innovation
The invention relates to an antimicrobial solution effective for sterilization of instruments in an automatic sterilization device, where a peracid product is formed in situ. The in situ peracid product is produced by combining a liquid acetyl donor selected from diacetyl methylamine, caprolactone, and imidazole with a powdered or granulated solid source of peroxide, and the in situ reaction takes place in the sterilization device.
The invention further includes an acidic pH modifier introduced into the solution via a controlled release mechanism to maintain an optimal in situ reaction condition pH of about 8. The specified approach enables sterilizing concentrations of peracid product without addition of sulfuric acid.
In addition to the antimicrobial solution, the described content includes a system for use with automated medical instrument sterilization, including a containment and delivery ampule with two compartments for precursor separation. One compartment contains the liquid precursor and another compartment contains peroxide and optional additives, and an acidic pH modifier is introduced via controlled release mechanisms such as water-soluble capsules, pouches, or tablets, or via machine logic.
Claims Coverage
The independent claim set contains 1 independent claim. It defines an antimicrobial solution and specifies in situ formation of a peracid product in an automatic sterilization device using a selected liquid acetyl donor, a powdered or granulated solid peroxide source, and an acidic pH modifier delivered via a controlled release mechanism to maintain pH of about 8, achieving sterilizing concentrations of at least about 2000 ppm without addition of sulfuric acid.
In situ peracid product from liquid acetyl donor and solid peroxide in an automatic sterilization device
A peracid product formed in situ from combining a liquid acetyl donor selected from diacetyl methylamine, caprolactone, and imidazole with a powdered or granulated solid source of peroxide, wherein the in situ reaction takes place in the sterilization device.
Acidic pH modifier introduced via controlled release to maintain pH about 8
An acidic pH modifier introduced into the solution via a controlled release mechanism to maintain an optimal in situ reaction condition pH of about 8.
Sterilizing concentrations at least about 2000 ppm without sulfuric acid
The concentration of peracid product formed in situ is effective to achieve sterilizing concentrations of at least about 2000 ppm without addition of sulfuric acid.
Across the independent claim, the main inventive features are: in situ peracid formation in the automatic sterilization device from a selected liquid acetyl donor and a powdered or granulated solid peroxide source, maintaining in situ reaction pH of about 8 using an acidic pH modifier delivered through a controlled release mechanism, and achieving at least about 2000 ppm sterilizing peracid concentrations without adding sulfuric acid.
Stated Advantages
Avoids need for sulfuric acid.
Reduces corrosiveness and venting/storage hazards compared with conventional peracetic acid systems.
Improves shelf life/stability.
Documented Applications
Sterilization of instruments in an automatic sterilization device, including automated medical instrument sterilization using in situ formation of peracetic acid from separated precursor components.
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