System and method for determining individualized medical intervention for a disease state

Inventors

Von Hoff, Daniel D. • Penny, Robert J.

Assignees

Caris Life Sciences Inc

Abstract

A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.

Core Innovation

The described invention provides a method for determining a personalized medical intervention for an individual having diagnosed pancreatic cancer by measuring a molecular profile from at least one sample of the individual’s pancreatic cancer. The molecular profile includes nucleic acid and protein analysis members, including ERBB2, ESR1, TOP1, KIT, and EGFR, and the results are compared to a reference to determine which members exhibit a change as compared to the reference.

After identifying the members of the molecular profile that exhibit changes, the method accesses a computer database to identify at least one drug therapy that interacts with each of the changed members. The drug therapy identification is computer-aided and is based on the interactions of the identified changed molecular profile members with drug therapies stored or accessible via the computer database.

The method further provides a computer generated report indicating the at least one drug therapy that was identified. In refinements described in the dependent claims, the molecular profile can include additional nucleic acids and additional proteins, and interpretation of profiling results can be supported by defined quantitative criteria. The database-based identification of drug therapies can use both an extensive literature database and data generated from clinical trials.

Claims Coverage

The partial claim set includes one independent claim directed to a personalized medical intervention for diagnosed pancreatic cancer, supported by dependent claims that refine the molecular profile composition, the analysis modalities and interpretation criteria, and the sources used for therapy identification. Across the claims, the independent-claim coverage focuses on four inventive feature groupings.

Overall, the claim coverage centers on combining pancreatic cancer molecular profiling of specified molecular profile members with reference-based change detection, then using a computer database to find drug therapies that interact with the changed members, and outputting a computer-generated report indicating the identified therapies. Dependent claims refine which molecular members are included and add defined quantitative criteria and specific sources for identifying therapy candidates.

Stated Advantages

Documented Applications