Eye drops for treatment of conjunctivochalasis
Inventors
Assignees
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Publication Number
US-8912166-B2
Publication Date
2014-12-16
Expiration Date
Abstract
An ophthalmic preparation and method, usable to treat conjunctivochalasis. The ophthalmic preparation comprises an aqueous solution of glycerol. The preparation may also include additional components including high molecular weight polymers for viscosity control and pharmacologically active substances. The method includes administering an ophthalmic preparation including an aqueous solution of glycerol to a patient.
Core Innovation
The disclosure addresses non-surgical treatment of conjunctivochalasis by administering an ophthalmic preparation to a patient. The conjunctivochalasis severity is characterized by a Lid Parallel Conjunctival Folds (LIPCOF) grade, and the administration continues until the LIPCOF grade is reduced.
The ophthalmic preparation comprises an aqueous solution of glycerol. The glycerol aqueous solution is described as isotonic or nearly isotonic, and the formulation is described as having a pH of about 7 and an inorganic salt concentration of less than 2 mM.
The preparation may further include high molecular weight polymers having a molecular weight greater than 10,000 Dalton, such as hyaluronate or carbomer, to provide a viscosity and/or non-Newtonian viscosity profile. Stabilizers, preservatives, antioxidants, buffers, and optionally additional ophthalmic medication such as diclofenac are also described as possible components.
Claims Coverage
The independent claim covers one inventive feature: a non-surgical method for treating or alleviating conjunctivochalasis using administration of an ophthalmic preparation comprising an aqueous solution of glycerol, with reduction of LIPCOF grade as the treatment outcome.
Non-surgical treatment by LIPCOF-guided glycerol ophthalmic preparation
A non-surgical method of treating or alleviating conjunctivochalasis comprising administering to a patient suffering from conjunctivochalasis, the conjunctivochalasis severity being characterized by a Lid Parallel Conjunctival Folds (LIPCOF) grade, an ophthalmic preparation comprising an aqueous solution of glycerol until the LIPCOF grade is reduced.
The core coverage is the administration of an ophthalmic preparation comprising an aqueous solution of glycerol in a non-surgical method, where the endpoint is reduction of the LIPCOF grade.
Stated Advantages
Statistically significant reduction of LIPCOF score versus baseline and versus prior artificial tear solutions (reported with p<0.01 and p≤0.001).
Documented Applications
Non-surgical treatment or alleviation of conjunctivochalasis in a patient, using eye drops administered until the LIPCOF grade is reduced.
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