Devices, therapeutic compositions and corresponding percutaneous treatment methods for aortic dissection
Inventors
Ogle, Matthew F. • Anderson, Edward J. • Reil, Todd D. • Carlyle, Wenda C.
Assignees
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Publication Number
US-8911468-B2
Publication Date
2014-12-16
Expiration Date
Abstract
The methods and devices disclosed herein pertain to the percutaneous treatment of various forms of aortic dissection by at least partially filling the false lumen of the aortic dissection with a stabilization agent percutaneously and steps to decrease the size of the false lumen using the devices. Fluid maybe aspirated from the false lumen to decrease the volume of the false lumen. And the entrance opening between the true lumen and the false lumen may be sealed with a sealing agent such as a biocompatible adhesive. The medical devices disclosed herein generally comprise an extendable sealing element that is used in conjunction with a catheter to expand the true lumen while reducing the size of the false lumen. The device has the ability to aspirate and/or deliver fluid containing the stabilization agent into the false lumen.
Core Innovation
The disclosed invention relates to percutaneously treating aortic dissection in a diseased aorta that comprises a true lumen and a false lumen, with an entrance opening between the true lumen and the false lumen. The method decreases the volume of the false lumen by deploying an expandable device in the true lumen, followed by completely removing the expandable device from the true lumen.
With the expandable device deployed, the method at least partially fills the false lumen percutaneously with a stabilization agent. The stabilization agent comprises one or more of a tissue stabilizer, a bioactive strength enhancer, a filler, and an adhesive or combinations thereof, and the filling concept uses filler materials and adhesives/sealants to mechanically stabilize and promote remodeling of the false lumen.
In a further aspect, the invention removes fluid from the false lumen percutaneously through the entrance opening to decrease the volume of the false lumen. After fluid removal, the method percutaneously seals the entrance opening between the true lumen and the false lumen, and can further include sealing an additional exit opening corresponding between the true lumen and the false lumen.
Claims Coverage
The document includes two independent method claims. Across the independent claims, the coverage centers on false-lumen volume reduction by deploying an expandable device in the true lumen with stabilization-agent filling and complete removal of the device, or by removing fluid from the false lumen through the entrance opening followed by percutaneous sealing of the entrance opening.
Deploying an expandable device in the true lumen to decrease false-lumen volume
A method for percutaneously treating aortic dissection in a diseased aorta comprising a true lumen, a false lumen, and an entrance opening between the true lumen and the false lumen, the method comprising percutaneously decreasing the volume of the false lumen by deploying an expandable device in the true lumen.
Filling the false lumen with a stabilization agent and removing the expandable device
With the expandable device deployed, at least partially filling the false lumen percutaneously with a stabilization agent that comprises a tissue stabilizer, a bioactive strength enhancer, a filler, an adhesive or combinations thereof, and after at least partially filling the false lumen, removing completely the expandable device from the true lumen.
Removing fluid through the entrance opening and sealing the entrance opening
A method for percutaneously treating aortic dissection in a diseased aorta comprising a true lumen, a false lumen, a lining between the true lumen and the false lumen, and an entrance opening between the true lumen and the false lumen, the method comprising removing fluid from the false lumen percutaneously wherein the fluid is removed through the entrance opening to decrease the volume of the false lumen; and percutaneously sealing the entrance opening between the true lumen and the false lumen.
Collectively, the independent claims cover percutaneous false-lumen volume reduction either by deploying an expandable device in the true lumen with subsequent stabilization-agent filling and complete removal of the device, or by removing fluid from the false lumen through the entrance opening followed by percutaneous sealing of the entrance opening.
Stated Advantages
Decreasing the volume of the false lumen by true-lumen deployment and/or fluid removal and by percutaneously filling/remodeling steps.
Promoting mechanical stabilization and remodeling of the false lumen by at least partially filling the false lumen with a stabilization agent comprising tissue stabilizer, bioactive strength enhancer, filler, and/or adhesive.
Blocking or restricting flow by percutaneously sealing the entrance opening between the true lumen and the false lumen.
Documented Applications
Percutaneous treatment of aortic dissection in a diseased aorta comprising a true lumen, a false lumen, and an entrance opening between the true lumen and the false lumen.
Percutaneous reduction of false-lumen volume by removing fluid from the false lumen through an entrance opening and sealing the entrance opening between the true lumen and the false lumen.
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