Antimicrobial photo-stable coating composition
Inventors
Dudnik, Vyacheslav • Natali, Yakeemovich • DiTizio, Valerio • DiCosmo, Frank
Assignees
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Publication Number
US-8877256-B2
Publication Date
2014-11-04
Expiration Date
Abstract
The invention is an antimicrobial photo-stable coating composition that deters photo-induced discoloration, does not stain tissue and can be applied to the surface of a variety of medical materials. The composition comprises in an aspect silver-PCA complex and dye.
Core Innovation
An antimicrobial photo-stable coating composition is described that includes complexed silver and a dye. The complexed silver comprises a silver salt complexed to a molecule with a basic nitrogen atom to protect the silver from subsequent oxidation/reduction reactions. The molecule is selected from ammonia, glycine, glutamic acid, tris(hydroxymethyl)aminomethane, polyethyleneimine, pyrrolidone carboxylic acid (PCA), or mixtures thereof.
The composition further includes a dye that absorbs light in the wavelength range of about 550-680 nm and about 380-450 nm, thereby deterring photo-induced discoloration. The composition is described as not substantially staining tissue and as being applicable to the surface of a variety of medical materials.
A related polymeric medical device is described with a hydrophilic coating made by incubating a photo-initiator-coated silicone material with an aqueous co-monomer solution capable of free radical polymerization and exposing it to ultraviolet light to create a modified surface. The device is then washed and dried and further coated or impregnated with the antimicrobial photo-stable coating composition comprising complexed silver and the specified dye.
Claims Coverage
The consolidated content includes two independent claims. Across the independents, the claims specify complexed silver protected against oxidation/reduction, a dye that absorbs specified wavelength ranges to deter photo-induced discoloration, a limitation that the composition does not substantially stain tissue, and a polymeric medical device with a hydrophilic coating on silicone that is further coated or impregnated with the antimicrobial photo-stable coating composition.
Antimicrobial photo-stable coating composition with complexed silver and wavelength-absorbing dye
An antimicrobial photo-stable coating composition comprising complexed silver and dye, wherein the complexed silver comprises silver salt complexed to a molecule with a basic nitrogen atom to protect the silver from subsequent oxidation/reduction reactions, wherein the molecule is selected from ammonia, glycine, glutamic acid, tris(hydroxymethyl)aminomethane, polyethyleneimine, pyrrolidone carboxylic acid (PCA), or mixtures thereof, and wherein the dye absorbs light in the wavelength range of about 550-680 nm and about 380-450 nm and thereby deters photo-induced discoloration, and wherein the composition does not substantially stain tissue and can be applied to the surface of a variety of medical materials.
Polymeric medical device with hydrophilic coating on silicone and antimicrobial photo-stable coating composition
A polymeric medical device having a hydrophilic coating made by incubating a photo-initiator-coated silicone material with an aqueous co-monomer solution capable of free radical polymerization and exposing it to ultraviolet light to create a modified surface, followed by washing and drying, wherein the device is further coated or impregnated with an antimicrobial photo-stable coating composition comprising complexed silver and dye, with the silver complexed to a molecule with a basic nitrogen atom and the dye absorbing light in the wavelength range of about 550-680 nm and about 380-450 nm to deter photo-induced discoloration.
The claim coverage focuses on preventing photo-induced discoloration while maintaining antimicrobial function through silver complexation with a basic-nitrogen molecule and through a dye that absorbs specified wavelength ranges. The device claim further ties the composition to a polymeric medical device having a hydrophilic coating created on a photo-initiator-coated silicone material, followed by washing and drying, and subsequent application of the antimicrobial photo-stable coating composition.
Stated Advantages
Deters photo-induced discoloration.
Protects silver from subsequent oxidation/reduction reactions.
Does not substantially stain tissue.
Documented Applications
Applying the antimicrobial photo-stable coating composition to the surface of a variety of medical materials.
Using the antimicrobial photo-stable coating composition on polymeric medical devices including implants, catheters, stents, wound dressings, cardiac valves, tubings, pins, and clips.
Hydrophilic-coated silicone-derived medical devices further coated or impregnated with the antimicrobial photo-stable coating composition.
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