Biomaterial detecting device

Inventors

Seo, Sung-min • Park, Jae-Hyung • Sergiy, Oleksandrov • Lee, Joong Hwan • Paek, Mun-Cheol • Ku, Su-Jin

Assignees

Sugentech Inc

Abstract

Provided is a biomaterial detecting device for confirming or detecting a biomaterial reaction, and more particularly to a biomaterial detecting device, which is formed in a stick type to thereby be immersed in a tube containing a biomaterial solution to be tested; has an upper portion with a cap structure to thereby induce reaction with a biomaterial, and thus facilitate confirmation and detection of the biomaterial; and is formed in a cap structure to thereby prevent evaporation of a sample and infiltration of an external material at the time of a biomaterial reaction in the tube, and thus improve reliability in analysis.

Core Innovation

The invention provides a stick-type biomaterial detecting device composed of a head, a tube coupler, a rod, and a detector. The head has a bottom surface and a first diameter, and the tube coupler protrudes downwardly from the bottom surface of the head with a second diameter that is configured to sealingly couple with a tube. The first diameter of the head is larger than the second diameter of the tube coupler, and the tube coupler is inserted into an inside of the tube.

A rod extends downwardly from a bottom surface of the tube coupler and is configured to be placed inside the tube without contacting the tube, with a lower surface. A detector is formed at the lower surface of the rod and is configured to detect a fluorescent or color formation signal generated by a reaction of a target biomaterial in a sample inside the tube. The detector can be coated or immobilized with detector coating materials including protein, nucleic acid, peptide nucleic acid (PNA), aptamer, or antibody, and the detector material can be arrayed to generate signals corresponding to biomaterial reactions.

The device further includes a first protrusion and a second protrusion formed on a first portion and a second portion of an outer circumferential surface of the tube coupler, and these protrusions protrude from the bottom surface of the head. The protrusions are circumferentially spaced from each other along the outer circumferential surface of the tube coupler, and portions of the outer circumferential surface other than the first and second portions are larger than the first and second portions. The protrusions are formed to prevent the bottom surface of the head from contacting the tube by the thickness of the protrusions.

A cap/adaptor structure is described to help prevent evaporation and external infiltration during reactions, and protrusions and a direction indicator are described as supporting proper spacing/alignment for automated handling. Application scenarios are described that integrate gene amplification, including real-time PCR, with DNA chip analysis, and also reference ELISA analysis, RIA analysis, and protein chip use for biomaterial detection and signal generation reliability.

Claims Coverage

The independent claim covered by the partial content is clm-00001, which contains multiple structural and functional inventive features; dependent claims clm-00002 to clm-00005 refine these features and add specific structural/material and alignment aspects. No additional independent claims are explicitly provided in the partial content beyond clm-00001.

Overall claim coverage centers on a sealingly coupled tube coupler and head geometry that use circumferential protrusions to prevent head-to-tube contact, combined with a non-contact rod carrying a detector that detects fluorescent or color formation signals from target biomaterial reactions in a sample. Dependent features further specify rod detachability, specify detector coating materials from a defined list, and add an array arrangement and a direction indicator to confirm alignment.

Stated Advantages

Documented Applications