In situ formation of an artificial blockage to control bleeding by polymer expansion with hydrogen peroxide and platinum catalyst
Inventors
Montes, Joseph G. • Rangan, Krishnaswamy Kasthuri • Radhakrishnan, Ramachandran • Sudarshan, Tirumalai Srinivas
Assignees
Publication Number
US-8852558-B2
Publication Date
2014-10-07
Expiration Date
2028-03-11
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Abstract
A composition for in situ formation and/or expansion of a polymer-based hemostatic agent to control bleeding includes a suitable amount of a polymer or polymer-forming component, hydrogen peroxide or chemical(s) capable of forming hydrogen peroxide, or a combination of both, and a decomposing agent for hydrogen peroxide. The decomposing agent includes an endogenously or exogenously supplied catalyst (other than catalase), or both, and/or the polymer or polymer-forming component.
Core Innovation
The invention provides a composition and method for in situ formation and/or expansion of a polymer-based hemostatic agent to control bleeding at wound sites. The core composition includes a suitable amount of a polymer or polymer-forming component, hydrogen peroxide or chemicals capable of forming hydrogen peroxide, or both, and a decomposing agent for hydrogen peroxide, where the decomposing agent includes an endogenously or exogenously supplied catalyst (other than catalase), or both, and/or the polymer or polymer-forming component itself.
The method involves delivering agents—such as hydrogen peroxide and a polymer-forming component—into a wound or body cavity and facilitating their reaction with a catalyst (other than catalase), notably platinum, so that gas is produced rapidly in situ. This generates an expanded mass (such as foam) that forms a pressurized physical obstruction or artificial blockage at the wound site to restrict, reduce, or arrest bleeding. The expanded material may be a viscous liquid, semi-solid, or solid, and acts in a similar manner to an artificial clot, tamponade, or blockage.
The invention seeks to address the critical challenge of uncontrolled or inadequately controlled blood loss from traumatic injury, whether internal or external, by offering a way to quickly and efficiently restrict or control bleeding. Existing approaches use hydrogen peroxide or hemostatic agents separately, but this invention combines their effects—utilizing in situ polymer expansion and gas generation for enhanced hemostasis, wound filling, and efficient delivery of hemostatic, antiseptic, or other clinically relevant agents to wound surfaces.
Claims Coverage
The patent contains two independent claims describing two main inventive features relating to injection methods for in situ formation of a pressurized obstruction to control bleeding.
Injection method using polyvinylsiloxane, hydrogen peroxide, and platinum catalyst for in situ expanded mass
This inventive feature involves: - Providing a polymer-forming component comprising polyvinylsiloxane. - Providing hydrogen peroxide with a concentration of about 20% to about 100% by volume or weight. - Injecting the polymer-forming component and hydrogen peroxide into a wound or bleeding body cavity. - Allowing the hydrogen peroxide to contact an endogenous or exogenous catalyst comprising platinum, resulting in the production of an expanded mass within 5 to 45 seconds, which forms a pressurized obstruction that controls bleeding in the wound or cavity.
Three-component injection method using hydrogen peroxide, polyvinylsiloxane, and platinum catalyst
This inventive feature comprises: - Providing a first component of hydrogen peroxide at a concentration of about 20% to 100% by volume or weight. - Providing a second component of an expandable component comprising polyvinylsiloxane. - Providing a third component of a catalyst comprising platinum. - Injecting all three components into the wound or body cavity. - Allowing the platinum catalyst to contact the hydrogen peroxide, leading to gas generation. - Allowing the gas to come into contact with the polyvinylsiloxane, thereby producing an expanded mass within 5 to 45 seconds that forms a pressurized obstruction to control the bleeding.
The independent claims protect methods for rapidly forming a pressurized, expanded polymeric obstruction in situ in a wound or body cavity using a specific combination of polyvinylsiloxane, high-concentration hydrogen peroxide, and a platinum catalyst to control bleeding.
Stated Advantages
Enables rapid in situ formation of a blockage to control bleeding in wounds or body cavities.
Improves the efficiency of delivery and dispersal of hemostatic and other wound treatment agents via selective or non-selective expansion.
Provides a method for creating a pressurized obstruction that restricts blood flow and loss within and from the wound or compartment.
Delivers antiseptic action through unreacted hydrogen peroxide to wound surfaces and cavities.
Allows for the creation of an artificial clot, tamponade, or obstruction for efficient wound filling.
Accelerates hemostasis by chemical stimulation with agents such as hydrogen peroxide.
Enables delivery of excess oxygen to assist with initial healing.
Permits thermal acceleration of natural blood clotting and protein heat-shock through exothermic reaction.
Enables repeated application to a wound or cavity over a range of time periods as needed.
Documented Applications
Controlling hemorrhage from wounds, internal or external, in humans and other animals.
Forming an artificial blockage via in situ expansion in a wound or body cavity to control bleeding.
Delivering hemostatic, antiseptic, or other clinically or medically relevant agents to wound surfaces efficiently via expansion.
Providing artificial clots, tamponades, or clogs for wound filling and pressurized obstruction to bleeding.
Enhancing wound healing by supplying excess oxygen or increasing wound temperature.
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