Method and device for radiotherapy
Inventors
Assignees
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Publication Number
US-8834837-B2
Publication Date
2014-09-16
Expiration Date
Abstract
A radiotherapy method, comprising positioning a predetermined amount of a radionuclide selected from the group consisting of Radium-223, Radium-224, Radon-219 and Radon-220, in proximity to and/or within a tumor of a subject, for a predetermined time period. The predetermined amount and the predetermined time period are selected sufficient for the radionuclide to administering a predetermined therapeutic dose of decay chain nuclei and alpha particles into the tumor.
Core Innovation
The invention provides a radiotherapy method that positions at least one removable radiotherapy device having a surface with a predetermined amount of a radionuclide retainably embedded on or beneath the surface in proximity to and/or within a tumor of a subject. The device is positioned for a predetermined time period selected sufficient for the radionuclide to administer a predetermined therapeutic dose of decay chain nuclei and alpha particles into the tumor. The radionuclide is selected from Radium-223 and Radium-224, and the embedding ensures that the radionuclide remains in the device while decay chain nuclei and alpha particles are recoiled outside the surface.
A related aspect removes a tumor by debulking at least a portion of the tumor and exposing tissue surrounding the tumor, and then positioning the same type of removable radiotherapy device in proximity to and/or within the surrounding tissue for a predetermined time period. The predetermined amount and predetermined time period are selected sufficient for the radionuclide to administer a predetermined therapeutic dose of decay chain nuclei and alpha particles into the surrounding tissue. Embedding ensures that the radionuclide remains in the device while the decay chain nuclei and alpha particles are recoiled outside the surface.
The disclosed approach relies on a decay-chain alpha-emitter configuration in which the parent radionuclide is retainably embedded at or beneath the device surface so that recoiled decay chain nuclei and alpha particles are administered to nearby tumor tissue. The device embodiments include removable radiotherapy devices with radionuclide embedded on or beneath a surface, including needle and bead forms, and configurations with an outer tubular member and a movable inner elongated member with a window. The disclosure also includes optional protective coating and a detector using photostimulable and/or photoluminescent material.
Claims Coverage
The independent claims are clm-00001 and clm-00011. Across these independent claims, the inventive core is the use of a removable radiotherapy device with Radium-223 or Radium-224 embedded on or beneath a device surface, positioned for a predetermined time period near or within tumor/surrounding tissue, such that the embedded radionuclide remains confined while decay chain nuclei and alpha particles are recoiled outside the surface to administer a therapeutic dose.
Removable radiotherapy device with embedded Radium-223 or Radium-224 for tumor treatment
A radiotherapy method positioning at least one removable radiotherapy device having a surface and a predetermined amount of a radionuclide retainably embedded on or beneath the surface in proximity to and/or within a tumor for a predetermined time period selected sufficient for the radionuclide to administer a predetermined therapeutic dose of decay chain nuclei and alpha particles into the tumor, wherein the radionuclide is selected from Radium-223 and Radium-224 and wherein the embedding ensures that the radionuclide remains in the device while the decay chain nuclei and alpha particles are recoiled outside the surface.
Debulking tumor and administering alpha-particle therapy to surrounding tissue using removable embedded radionuclide
A method of removing a tumor comprising debulking at least a portion of the tumor and exposing tissue surrounding the tumor, and positioning at least one removable radiotherapy device having a surface and a predetermined amount of a radionuclide retainably embedded on, or beneath said surface in proximity to and/or within said surrounding tissue for a predetermined time period selected sufficient for the radionuclide to administer a predetermined therapeutic dose of decay chain nuclei and alpha particles into said surrounding tissue, wherein the radionuclide is selected from Radium-223 and Radium-224 and wherein the embedding ensures that the radionuclide remains in the device while the decay chain nuclei and alpha particles are recoiled outside the surface.
Both independent claims center on retainably embedding Radium-223 or Radium-224 on or beneath a removable radiotherapy device surface, positioning the device for a selected time near or within tumor-related tissue, and ensuring the parent radionuclide remains in the device while decay chain nuclei and alpha particles are recoiled outside the surface to deliver a therapeutic dose.
Stated Advantages
The embedding ensures that the radionuclide remains in the radiotherapy device while decay chain nuclei and alpha particles are recoiled outside the surface.
Enables administration of a therapeutic dose of decay chain nuclei and alpha particles into a tumor and, in the debulking-related method, into surrounding tissue.
Documented Applications
Radiotherapy treatment of a subject by positioning a removable radiotherapy device near and/or within a tumor to administer a therapeutic dose of decay chain nuclei and alpha particles into the tumor.
Removal of a tumor by debulking and exposing surrounding tissue followed by positioning a removable radiotherapy device near and/or within surrounding tissue to administer a therapeutic dose of decay chain nuclei and alpha particles into the surrounding tissue.
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