System and method for determining individualized medical intervention for a disease state
Inventors
Von Hoff, Daniel D. • Penny, Robert J.
Assignees
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Publication Number
US-8831890-B2
Publication Date
2014-09-09
Expiration Date
Abstract
A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.
Core Innovation
A method is disclosed for generating an individualized treatment report by obtaining a biological tumor sample from an individual diagnosed with breast cancer, wherein the individual has undergone prior treatment for the breast cancer. A molecular profile for the individual is provided by performing a molecular test for a group of target genes in the biological tumor sample, and the group includes EGFR, KIT, TOP1, MLH1, ESR1 and PDGFRB. Altered target genes are identified by comparing the molecular profile to a normal breast tissue reference for each of the group of target genes and selecting those that exhibit a change compared to their respective normal reference.
An electronic network is accessed that comprises a drug database containing information on possible drug therapy for the altered target genes. A list of possible drug therapies is compiled for treating the breast cancer based on the altered target genes identified by the comparison to the normal breast tissue reference. A report is then generated that provides the molecular profile and the list of possible drug therapies for treating the breast cancer, thereby generating the individualized treatment report.
Claims Coverage
The partial content provides one independent claim that covers generating an individualized treatment report based on patient tumor molecular profiling and compiling possible drug therapies via an electronic drug database.
Individually generated treatment report from breast tumor molecular profiling
Obtain a biological tumor sample from an individual diagnosed with breast cancer who has undergone prior treatment, provide a molecular profile by performing a molecular test for a group of target genes including EGFR, KIT, TOP1, MLH1, ESR1 and PDGFRB, compare the molecular profile to a normal breast tissue reference to identify altered target genes exhibiting a change, and generate a report that provides the molecular profile.
Electronic drug database compilation of possible therapies for altered targets
Access an electronic network comprising a drug database that contains information on possible drug therapy for the altered target genes to compile a list of possible drug therapies for treating the breast cancer, and include the list in the individualized treatment report.
The inventive coverage is directed to creating an individualized treatment report from a breast tumor molecular profile with altered target genes determined versus a normal breast tissue reference, and compiling possible drug therapies for those altered target genes by accessing an electronic network drug database.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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