In situ formation of an artificial blockage to control bleeding by polymer expansion with hydrogen peroxide
Inventors
Montes, Joseph G. • Rangan, Krishnaswamy Kasthuri • Radhakrishnan, Ramachandran • Sudarshan, Tirumalai Srinivas
Assignees
Publication Number
US-8828358-B2
Publication Date
2014-09-09
Expiration Date
2028-03-11
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Abstract
A composition for in situ formation of an artificial blockage to control bleeding includes a suitable amount of a polymer-forming component, a suitable amount of a crosslinking agent, hydrogen peroxide, and a decomposing agent for hydrogen peroxide. The decomposing agent includes exogenous or endogenous catalase, or both.
Core Innovation
The invention provides a composition and method for controlling bleeding at wound sites by enabling in situ formation of an artificial blockage or obstruction. The solution comprises a suitable amount of a polymer-forming component, a suitable amount of a crosslinking agent, hydrogen peroxide, and a decomposing agent for hydrogen peroxide, where the decomposing agent includes exogenous or endogenous catalase or both. The composition reacts at the site of bleeding, where interaction with blood catalase leads to the rapid expansion and formation of a pressurized mass—such as a foam—thereby creating a physical barrier to blood flow.
The problem addressed by the invention is the critical need for effective, rapid, and localized control of hemorrhage resulting from traumatic injuries or surgical procedures, particularly where prior art hemostatic methods fail to leverage the catalase-hydrogen peroxide reaction for targeted expansion and wound obstruction. Existing techniques do not utilize the self-regulating nature of this biochemical reaction to disperse or drive a substance into a wound space or cavity efficiently, especially one that capitalizes on endogenous catalase spatial distribution.
The invention describes both a composition and delivery method, where components containing hydrogen peroxide and an expandable polymer precursor are delivered simultaneously into a wound or body cavity. Upon contact with catalase, either from the blood or as provided exogenously, the hydrogen peroxide decomposes to release oxygen, causing the polymer to expand and fill the wound rapidly. This expansion results in a viscous or solid mass that conforms to the wound geometry, effectively stemming blood loss by mechanical and/or chemical action. Additional agents such as anesthetics, procoagulants, and vasoconstrictors can be included to enhance clinical efficacy.
Claims Coverage
There is one independent claim detailing the primary inventive features of the invention.
Injection method for in situ formation of a pressurized obstruction to control bleeding
The method involves: 1. Providing a first component comprising hydrogen peroxide at a concentration of about 20% to about 100% by volume or weight. 2. Providing a second component comprising an expandable component containing polyacrylate. 3. Delivering the first and second components separately but substantially simultaneously by injection into a wound or body cavity. 4. Allowing blood to come into contact with the hydrogen peroxide, producing a gas. 5. Allowing the gas to come into contact with polyacrylate, resulting in an expanded mass within 5 to 45 seconds that forms a pressurized obstruction to control bleeding in the wound or body cavity.
The claim focuses on the method of using hydrogen peroxide and polyacrylate, delivered in a specific manner and concentration, to rapidly and effectively create a pressurized expansion and obstruction to control bleeding at the site of injury.
Stated Advantages
Provides a composition and method for reducing, restricting, and/or arresting hemorrhage from wounds, internal or external, in humans and other animals.
Enables in situ formation of an artificial blockage to control bleeding, effectively creating a physical obstruction to blood flow.
Works efficiently in traumatic or accidental injuries and medical procedures, particularly for puncture or penetration wounds.
Increases the efficiency of delivery or dispersal of hemostatic or other wound-treatment agents, with selective expansion occurring most rapidly where blood (and catalase) are concentrated.
Provides a pressurized wound or compartment that restricts blood flow and loss.
Delivers antiseptic (unreacted hydrogen peroxide) to the wound surfaces and spaces.
Enables self-regulating expansion by targeting regions with higher endogenous catalase, favoring oxygen-releasing reaction where needed most.
Allows for artificial clot, tamponade, or obstruction formation that fills the wound space efficiently.
Provides excess oxygen at the wound site, which may aid in initial healing.
Serves as a chemical basis for accelerating or enabling other reactions that promote obstruction or clotting.
Promotes blood clotting by the action of hydrogen peroxide itself.
Documented Applications
Controlling bleeding from wounds, both internal and external, in humans and other animals.
Controlling bleeding due to traumatic injury, including accidental and deliberate injuries (such as those occurring during medical procedures), especially for puncture or penetration wounds.
Interested in licensing this patent?