Anti-adhesion material
Inventors
Tani, Toru • Kamitani, Sumihiro • Mukai, Tomokazu
Assignees
Shiga University of Medical Science NUC • SB Kawasumi Laboratories Inc
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Publication Number
US-8821900-B2
Publication Date
2014-09-02
Expiration Date
Abstract
An object of the present invention is to provide an anti-adhesion material having sufficient in vivo degradability and excellent anti-adhesion characteristics, and also superior to conventional ones in terms of handling properties under wet conditions. The anti-adhesion material (1) of the present invention has a sheet-like base layer (10) containing a water soluble polymer (e.g., pullulan), a first cover layer (20) placed on a surface on one side of the base layer (10) and containing an aliphatic ester, and a second cover layer (30) placed on a surface on the other side of the base layer (10) and containing an aliphatic ester. The optical thickness of each of the first cover layer (20) and the second cover layer (30) is set to be 27 nm or greater and smaller than 160 nm.
Core Innovation
The invention relates to an anti-adhesion material comprising a base layer containing a water soluble polymer and a cover layer containing an aliphatic ester, placed on at least one of both surfaces of the base layer. The cover layer is defined by an optical thickness measured using a spectroscopic ellipsometer with a wavelength range of 380 nm to 900 nm, or by a layer thickness range.
In one independent formulation, the optical thickness of the cover layer is 27 nm or greater but not greater than 128 nm. In another independent formulation, the layer thickness of the cover layer is 130 nm or greater but not greater than 660 nm.
The document further describes alternative constructions in which the base layer has a first and second cover layer on opposing surfaces, with the cover layers being the same or different materials. It also describes variants that include a medical agent, and in particular an antibacterial-agent variant with new quinolone-based antibacterial agents.
The stated purpose is to address conventional anti-adhesion sheets and cylindrical materials that include a water-soluble polymer base layer but have wet handling problems. The described materials are asserted to improve wet handling while maintaining sufficient in vivo degradability and anti-adhesion characteristics.
Claims Coverage
The document includes two independent claims. Both are directed to an anti-adhesion material with a water-soluble polymer base layer and an aliphatic ester cover layer on one or both surfaces, with the cover layer defined by either spectroscopic ellipsometry optical thickness or physical layer thickness.
Spectroscopic ellipsometry-defined cover-layer optical thickness
An anti-adhesion material including a base layer containing a water soluble polymer and a cover layer containing an aliphatic ester placed on at least one of both surfaces of the base layer, wherein an optical thickness of the cover layer, as measured using a spectroscopic ellipsometer with a wavelength of 380 nm to 900 nm, is 27 nm or greater but not greater than 128 nm.
Aliphatic ester cover layer defined by cover-layer thickness range
An anti-adhesion material comprising a base layer containing a water-soluble polymer wherein, on at least one of both surfaces of said base layer, a cover layer containing an aliphatic ester has been placed, and a layer thickness of the cover layer is 130 nm or greater but not greater than 660 nm.
Across the independent claims, the inventive subject matter is the combination of a water-soluble polymer base layer with an aliphatic ester cover layer placed on one or both surfaces, together with a defined cover-layer thickness window.
Stated Advantages
Improved wet handling versus conventional materials having only a base layer of a water-soluble polymer.
Maintains sufficient in vivo degradability.
Maintains anti-adhesion characteristics, including adhesion reduction in a rat abdominal/appendix adhesion model.
Provides handling properties under wet conditions, including breaking strength when pressed against pseudo-wet tissue.
Provides increased frictional resistance and adhesive resistance in pseudo-wet friction tests.
Documented Applications
Use in an in vivo rat adhesion model for the abdomen/appendix laparotomy, with adhesion scoring reported after an observation period.
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