Method to ameliorate oxidative stress and improve working memory via pterostilbene administration
Inventors
Joseph, James A. • Rimando, Agnes M. • Shukitt-Hale, Barbara
Assignees
US Department of Agriculture USDA
Publication Number
US-8809400-B2
Publication Date
2014-08-19
Expiration Date
2028-06-10
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Abstract
Disclosed is a pharmaceutical composition for treating oxidative stress comprising a therapeutically effective amount of a substantially pure compound of pterostilbene and a physiologically acceptable carrier. Pterostilbene is administered in an amount between about 2.5 mg to about 10 mg per kilogram of subject body weight. Also disclosed is a method for increasing a working memory of a subject, the method comprising administrating an effective amount of a substantially pure compound of pterostilbene, wherein the working memory for a subject increase and the therapeutic effectiveness is about 10 mg of pterostilbene per kilogram of subject body weight.
Core Innovation
The invention provides a pharmaceutical composition and method for treating oxidative stress and improving working memory by administering a therapeutically effective amount of substantially pure pterostilbene. The composition includes pterostilbene in amounts between about 2.5 mg to about 10 mg per kilogram of subject body weight. The method involves administering an effective amount of pterostilbene to increase the working memory of a subject, with a preferred therapeutic effective amount of about 10 mg per kilogram of subject body weight.
The problem addressed by the invention stems from age-related neuronal and behavioral decline and neurodegenerative diseases associated with oxidative stress and cognitive impairments such as decreased working memory. Existing nutritional regimes with berryfruit supplements show some ability to prevent motor and cognitive decline, but there is a need to identify specific compounds responsible for these effects. Pterostilbene, an analog of resveratrol found in Vaccinium berries and other botanical and non-botanical sources, has demonstrated antioxidant and anti-inflammatory activities, yet its potential to reverse cognitive and motor deficiencies caused by aging and oxidative stress has not been fully elucidated.
This invention addresses the need to identify compounds that protect against oxidative mediated changes in motor and cognitive function by providing a treatment method using pterostilbene that specifically enhances muscarinic acetylcholine receptor activity, protects against oxidative stress-induced inhibition of dopamine release, and improves working memory. The method and composition thus provide a targeted approach to forestall, prevent, and reverse effects of neuronal aging and neurodegenerative processes through pterostilbene administration.
Claims Coverage
The patent contains one independent claim focused on a method for improving working memory by administering pterostilbene. The inventive features highlight the effective amount and use of isolated or purified pterostilbene for this purpose.
Method for increasing working memory using pterostilbene
A method comprising administering to a subject in need an effective amount of isolated or purified pterostilbene, wherein the subject's working memory is increased.
Therapeutic effective dosage of pterostilbene
The effective amount of isolated or purified pterostilbene is about 10 mg of compound per kilogram of subject body weight.
Dosage range for pterostilbene administration
The effective amount of isolated or purified pterostilbene is from about 2.5 mg to about 10 mg of compound per kilogram of subject body weight.
The independent claim focuses on a method to enhance working memory by administration of isolated or purified pterostilbene in therapeutically effective doses, specifically detailing dosage ranges from 2.5 to 10 mg/kg body weight, with about 10 mg/kg as a preferred effective amount.
Stated Advantages
Pterostilbene administration reverses cognitive and motor deficiencies associated with aging in a dose-dependent manner.
Pterostilbene protects muscarinic acetylcholine receptor activity under oxidative stress conditions.
Administration of pterostilbene prevents dopamine release inhibition caused by oxidative stress.
Pterostilbene increases calcium buffering ability of muscarinic receptor subtypes involved in cognitive function.
Documented Applications
Use of pterostilbene supplementation in aging subjects to improve psychomotor and cognitive performance, particularly working memory.
Treatment of oxidative stress-related neuronal and behavioral aging conditions and prevention of neurodegenerative diseases.
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