Implants and methods for correcting tissue defects
Inventors
Engqvist, Håkan • Åberg, Jonas • Bohlin, Jan • Engstrand, Thomas
Assignees
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Publication Number
US-8795377-B2
Publication Date
2014-08-05
Expiration Date
Abstract
The present invention relates to mosaic implant (15) comprising a plurality of mosaic plates (17) connected by a wire or mesh anchoring arrangement (9). Methods for forming such implants and methods for using said implants for correction of bone and soft tissue defects are described.
Core Innovation
The disclosed implant system comprises a plurality of discrete biocompatible molded cement mosaic plates of thickness d connected by wire arms extending substantially laterally from the mosaic plates, with neighbouring mosaic plates separated by a gap of width t. The mosaic implant system combines a wire/mesh anchoring arrangement with moulded solid mosaic cement plates for correction of bone and/or soft tissue defects, and includes wire-retaining channels associated with the anchoring wire/mesh.
The system includes moulding concepts that enable optional frangible bridging skin between adjacent plates, referred to as a skin s, where the skin s is thinner than the plate thickness d in described relationships. The mosaic plates are configurable to enhance bone in-growth and mechanical strength by providing cement mosaic plates separated by gaps while maintaining lateral connection to the wire arms.
The mosaic cement plates are formed from non-aqueous hydraulic Ca-salt cement compositions that harden in wet or moist environments, with described compositions based on Ca-salt precursors. The document also describes manufacturing variants using mould cavities for plate-forming and two-part mirror-image mould compression to form the mosaic cement plates, and gives an example using acidic calcium phosphate cement with Ti wires.
Claims Coverage
The partial content identifies two independent claims. The inventive features focus on a discrete molded cement mosaic plate implant connected by laterally extending wire arms with a defined gap between plates, and specific geometric constraints and Monetite composition for hexagonal mosaic plates with a constrained gap width.
Discrete molded cement mosaic plates connected by wire arms with defined plate gap
An implant comprising a plurality of discrete biocompatible molded cement mosaic plates of thickness d connected by wire arms molded into and extending substantially laterally from the mosaic plates, wherein neighbouring mosaic plates are separated by a gap of width t.
Hexagonal molded cement mosaic plates with constrained geometry and Monetite
An implant comprising a plurality of discrete biocompatible hexagonal moulded cement mosaic plates of maximum width w (w from 4 to 10 mm) and thickness d (d from 50% to 130% of w), connected by wire arms moulded into and extending substantially laterally from the mosaic plates, wherein neighbouring mosaic plates are separated by a gap of width t (t less than 3 mm), and wherein the mosaic plates comprise Monetite.
Across the independent claims, the core claim coverage is directed to a mosaic implant formed by discrete biocompatible molded cement plates connected by wire arms, with neighbouring plates separated by a gap of width t. The second independent claim further narrows the form factor to hexagonal plates and adds quantitative geometric limits and Monetite as the cement phase for the mosaic plates.
Stated Advantages
Enhanced bone in-growth and mechanical strength.
Ability to shape in the operating room by cutting mesh/weakening skin.
Documented Applications
Correction of bone and/or soft tissue defects using a mosaic implant system with moulded cement mosaic plates connected to wire arms.
Clinical use in cranial bone defect patients, with CT-scan follow-up showing correct positioning and no early resorption/infection [procedural detail omitted for safety].
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