Antimicrobial solutions containing dichlorine monoxide and methods of making and using the same
Inventors
Assignees
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Publication Number
US-8784900-B2
Publication Date
2014-07-22
Expiration Date
Abstract
Methods and products are provided for treating a wound or infection in a mammal or disinfecting a surface with a hypochlorous acid solution that has been activated by a catalyst. Additionally provided is a process for preparing an antimicrobial product that produces an activated hypochlorous acid solution for use as an antimicrobial.
Core Innovation
The invention provides an antimicrobial solution that combines a first component comprising an effective amount of a hypochlorous acid solution buffered at a pH of about 4 to about 6 with a second component comprising a catalyst. The catalyst catalyzes the conversion of hypochlorous acid into dichlorine monoxide, and the combination produces an activated solution comprising a therapeutically effective amount of dichlorine monoxide. The activated solution has a pH in a range of from about 4 to about 10.
The hypochlorous acid solution comprises a buffer selected from phosphate buffer, acetate buffer, citrate buffer, borate buffer, and combinations thereof. Catalyst options include chloride ion, phosphate ion, tertiary amine, sodium hypochlorite, citric acid, and combinations thereof, and in certain embodiments triethanolamine functions as the catalyst. The activated solution is generated with a therapeutic dichlorine monoxide content.
The disclosed antimicrobial system is used in methods for treating a wound or infection in a mammal and for disinfecting a surface. For wound or infection treatment, a solution comprising an effective amount of hypochlorous acid is combined with a catalyst to produce an activated solution comprising a therapeutically effective amount of dichlorine monoxide, followed by administering the activated solution to treat the wound or infection. For surface disinfection, the activated solution comprising a surface-disinfecting effective amount of dichlorine monoxide is used to contact the surface to disinfect it.
The system leverages an equilibrium between hypochlorous acid and dichlorine monoxide, where catalyst and buffering conditions shift formation of dichlorine monoxide in an activated solution across a pH range of about 4 to about 10. The document discusses assessment of dichlorine monoxide formation kinetics, effects of chloride and pH on formation, spore-killing efficacy, and performance under high organic load (albumin).
Claims Coverage
The partial content identifies three independent claims covering an antimicrobial solution, treatment of a wound or infection in a mammal, and disinfecting a surface. Each independent claim is structured around an inventive two-component conversion of hypochlorous acid into dichlorine monoxide under defined pH and buffer conditions.
Buffered hypochlorous acid plus catalyst producing dichlorine monoxide
An antimicrobial solution comprising a first component comprising an effective amount of a hypochlorous acid solution, wherein the hypochlorous acid solution has a pH of about 4 to about 6 and comprises a buffer selected from phosphate buffer, acetate buffer, citrate buffer, borate buffer, and combinations thereof, and a second component comprising a catalyst that catalyzes the conversion of hypochlorous acid into dichlorine monoxide, wherein the combined components produce an activated solution comprising a therapeutically effective amount of dichlorine monoxide and the activated solution has a pH in a range of from about 4 to about 10.
Treatment of mammal wound or infection by administering activated dichlorine monoxide
A method for treating a wound or infection in a mammal by adding a catalyst to a solution comprising an effective amount of hypochlorous acid to produce an activated solution comprising a therapeutically effective amount of dichlorine monoxide, and administering the activated solution to treat the wound or infection, with the hypochlorous acid solution having a pH of about 4 to about 6, comprising a buffer selected from phosphate buffer, acetate buffer, citrate buffer, borate buffer, and combinations thereof, and the activated solution having a pH in a range of from about 4 to about 10.
Surface disinfection by contacting activated dichlorine monoxide solution
A method for disinfecting a surface by adding a catalyst to a solution comprising an effective amount of hypochlorous acid to produce an activated solution comprising a surface-disinfecting effective amount of dichlorine monoxide, and contacting the surface with the activated solution to disinfect the surface, with the hypochlorous acid solution having a pH of about 4 to about 6, comprising a buffer selected from phosphate buffer, acetate buffer, citrate buffer, borate buffer, and combinations thereof, and the activated solution having a pH in a range of from about 4 to about 10.
Across the independent claims, the core claim coverage is directed to producing an activated solution containing dichlorine monoxide by catalyzing the conversion of a buffered hypochlorous acid solution such that the activated solution has pH about 4 to about 10. This activated dichlorine monoxide solution is then covered for therapeutic administration to treat mammal wounds or infections and for contacting surfaces to disinfect them.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Treating a wound or infection in a mammal using an activated solution comprising a therapeutically effective amount of dichlorine monoxide.
Disinfecting a surface by contacting the surface with an activated solution comprising a surface-disinfecting effective amount of dichlorine monoxide.
Disinfection of surfaces and medical devices, including implants/heart valve contexts, is discussed in the partial content description.
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