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Assignees
Member
CrossjectCrossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Crossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Publication Number
US-8784371-B2
Publication Date
2014-07-22
Expiration Date
Abstract
Needleless injection device (1) comprising a gas generator (2), a reservoir (5) in the form of a glass tube (6) closed by an upstream stopper (7) and a downstream stopper (8) between which a liquid active principle (9) is accommodated, and an injection nozzle (15) equipped with a receptacle (19) and with at least one peripheral injection conduit (20), said tube (6) having, at one of its ends, a flange (4) via which it is in contact with said nozzle (15). The main feature of this needleless injection device (1) is that the tube (6) has a cylindrical inner channel with an upstream part (21) which is continued by a downstream part (22) of smaller diameter, said downstream part (22) being surrounded by said flange (4) and opening into the receptacle (19).
Core Innovation
The invention relates to a needleless injection device comprising a gas generator, a reservoir constituted by a glass tube blocked by an upstream stopper and a downstream stopper, and an injection nozzle equipped with a receptacle and with at least one peripheral injection duct. The reservoir houses a liquid active principle between the upstream stopper and the downstream stopper, and the injection nozzle receives and cooperates with the glass tube end to enable injection of the liquid active principle through the peripheral injection ducts into a receptacle.
A core feature is that the glass tube possesses, at one end, a flange by which the glass tube is in contact with the injection nozzle. This flange is a region of larger diameter of the glass tube, and the glass tube also has an internal channel comprising an upstream part extended by a downstream part of smaller diameter.
The downstream part is surrounded by the flange and opens into the receptacle. The internal channel configuration, with the larger-diameter flange region surrounding the smaller-diameter downstream part, protects the downstream stopper during a shock when the downstream stopper enters the nozzle receptacle and is configured to prevent tube shattering and to ensure controlled passage of the downstream part into the receptacle during expulsion.
Claims Coverage
The independent claim specifies a needleless injection device with a gas generator, a double-stopper glass-tube reservoir containing a liquid active principle, and an injection nozzle with a receptacle and at least one peripheral injection duct. The claim further requires a specific glass-tube end geometry: a flange of larger diameter contacting the nozzle and an internal channel transitioning from an upstream part to a smaller-diameter downstream part surrounded by the flange and opening into the receptacle.
Gas generator and double-stopper glass-tube reservoir
A needleless injection device comprising a gas generator and a reservoir constituted by a glass tube blocked by an upstream stopper and a downstream stopper, between which a liquid active principle is housed.
Injection nozzle with receptacle and peripheral injection duct
An injection nozzle equipped with a receptacle and with at least one peripheral injection duct.
Larger-diameter flange at glass-tube end contacting nozzle
The glass tube possesses, at one end, a flange by means of which said glass tube is in contact with said injection nozzle, said flange being a region of larger diameter of said glass tube.
Internal channel transitioning to smaller-diameter downstream part
The glass tube has an internal channel comprising an upstream part extended by a downstream part of smaller diameter, said downstream part being surrounded by said flange and opening into the receptacle.
Across the independent claim, coverage centers on the integration of a double-stopper glass-tube reservoir with an injection nozzle having a receptacle and peripheral injection ducts, while requiring a flange at the glass-tube end and a two-part internal channel in which a smaller-diameter downstream portion is surrounded by the flange and opens into the receptacle.
Stated Advantages
Protects the downstream stopper during a shock when the downstream stopper enters the nozzle receptacle.
Prevents tube shattering.
Documented Applications
Injection into skin using a needleless injection device.
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