Flurbiprofen and muscle relaxant combinations
Inventors
Cifter, Umit • Turkyilmaz, Ali • Turp, Hasan Ali
Assignees
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Publication Number
US-8778391-B2
Publication Date
2014-07-15
Expiration Date
Abstract
This invention is a novel pharmaceutical composition comprising flurbiprofen or a pharmaceutically acceptable salt thereof in combination with an α-2 adrenergic receptor agonist or a gamma-aminobutiric acid receptor agonist with anti-inflammatory, analgesic and myorelaxant activity.
Core Innovation
The invention relates to a pharmaceutical composition combining flurbiprofen or a pharmaceutically acceptable salt thereof with tizanidine or a pharmaceutically acceptable salt thereof, or with thiocolchicoside or a pharmaceutically acceptable salt thereof. The combination provides anti-inflammatory, analgesic, and myorelaxant activity.
The document addresses the problem that flurbiprofen has not previously been combined with these specific classes in relation to the indicated activities. It is targeted to painful muscle spasms connected with vertebral static and functional disorders and painful states after post-operations of osteoarthritis.
The composition is described in multiple dosage forms and administration routes, including oral, parenteral, intramuscular, and topical administration. The document includes tablets, capsules, injectables, suspensions, syrups, sachets, ointments, creams, gels, and bilayer tablets in which flurbiprofen is in one layer and tizanidine or thiocolchicoside is in another layer.
Claims Coverage
The independent claim covers a pharmaceutical composition that combines flurbiprofen with either tizanidine or thiocolchicoside, each optionally as a pharmaceutically acceptable salt. Dependent claims further specify quantitative dosage ranges, a bilayer tablet structure, and treatment of painful muscle spasms in vertebral static and functional disorders and after post-operations of osteoarthritis.
Flurbiprofen in combination with tizanidine or pharmaceutically acceptable salts
A pharmaceutical composition comprising flurbiprofen or a pharmaceutically acceptable salt thereof in combination with tizanidine or a pharmaceutically acceptable salt thereof.
Flurbiprofen in combination with thiocolchicoside or pharmaceutically acceptable salts
A pharmaceutical composition comprising flurbiprofen or a pharmaceutically acceptable salt thereof in combination with thiocolchicoside or a pharmaceutically acceptable salt thereof.
Flurbiprofen amount between 100 mg and 500 mg
The pharmaceutical composition contains flurbiprofen or a pharmaceutically acceptable salt thereof in an amount between 100 and 500 mg.
Tizanidine amount between 2 mg and 36 mg
The pharmaceutical composition contains tizanidine or a pharmaceutically acceptable salt thereof in an amount between 2 and 36 mg.
Thiocolchicoside amount between 2 mg and 20 mg
The pharmaceutical composition contains thiocolchicoside, or a pharmaceutically acceptable salt thereof, in an amount between 2 and 20 mg.
Bilayer tablet with separate layers for flurbiprofen and tizanidine
A solid dosage form as a bilayer tablet having flurbiprofen in one layer and tizanidine in another layer.
Treating painful muscle spasms in specified vertebral and post-osteoarthritis contexts
Treating painful muscle spasms associated with static and functional disorders of vertebra or after post-operations of osteoarthritis by administering a therapeutically-effective amount of the pharmaceutical composition.
Overall, the claim set covers flurbiprofen combined with tizanidine or thiocolchicoside, optionally as pharmaceutically acceptable salts, with dependent claims specifying dosage ranges, a bilayer tablet structure, and a treatment use directed to painful muscle spasms associated with vertebral static and functional disorders and after post-operations of osteoarthritis.
Stated Advantages
Anti-inflammatory activity
Analgesic activity
Myorelaxant activity
Activity directed to painful muscle spasms
Documented Applications
Treatment of painful muscle spasms associated with static and functional disorders of vertebra.
Treatment of painful states after post-operations of osteoarthritis.
Use in conditions listed in the document text including torticollis, dorsalgy, lombalgy, disk hernia, and spasticity.
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