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Publication Number
US-8734828-B2
Publication Date
2014-05-27
Expiration Date
Abstract
A cell-free graft contains (i) a cohesive, scaffold-forming matrix with open porosity containing a biologically and pharmaceutically acceptable material, and (ii) a gel of a biologically and pharmaceutically acceptable material. The cell-free graft is produced by (v) contacting the matrix with the gel, and (vi) drying the matrix-gel complex formed in (v). The cell-free graft can be used for covering and increasing the viscoelasticity of defects, for tissue regeneration and in particular for regenerating mesenchymal tissue, especially cartilage and/or bone.
Core Innovation
The disclosed invention relates to a cell-free graft comprising a cohesive, scaffold-forming matrix with open porosity. The matrix includes a biologically and pharmaceutically acceptable material and has a structure selected from wovens, nonwoven structures, felt structures, wadding, wool, and combinations thereof, and comprises polyglycolic acid, polylactic acid, poly(glycolide, lactate), and mixtures thereof.
The cell-free graft further comprises a hyaluronic acid gel present on at least one side of the matrix. The hyaluronic acid gel penetrates the matrix at least partly, so that the graft combines the open-porosity scaffold-forming matrix with a hyaluronic acid gel positioned on one or more sides and extending into the matrix.
The invention also relates to producing the cell-free graft by contacting the matrix with a gel to obtain a matrix-gel complex and drying the matrix-gel complex. In the produced graft, the gel is a hyaluronic acid gel, and the resulting graft comprises the matrix and the hyaluronic acid gel present on at least one side of the matrix and/or penetrating the matrix at least partly.
Claims Coverage
The patent includes three independent claims covering a cell-free graft structure and a method for producing the cell-free graft. Across these claims, the coverage is organized around a cohesive open-porosity scaffold-forming matrix combined with a hyaluronic acid gel positioned on at least one side and/or penetrating the matrix, using specified matrix structural forms and materials, and for the method claim adding drying of a matrix-gel complex.
Open-porosity scaffold-forming cohesive matrix with defined structures and materials
A cohesive, scaffold-forming matrix with open porosity comprising a biologically and pharmaceutically acceptable material, wherein the matrix has a structure selected from the group consisting of wovens, nonwoven structures, felt structures, wadding, wool, and combinations thereof, and wherein the matrix comprises polyglycolic acid, polylactic acid, poly(glycolide, lactate), and mixtures thereof.
Hyaluronic acid gel on at least one matrix side with partial penetration
A hyaluronic acid gel wherein the gel is present on at least one side of the matrix, and wherein the gel penetrates the matrix at least partly.
Hyaluronic acid gel on at least one side and/or penetration of the matrix
A cell-free graft comprising a cohesive, scaffold-forming matrix with open porosity as recited, and a hyaluronic acid gel wherein the gel is present on at least one side of the matrix and/or wherein the gel penetrates the matrix at least partly.
Matrix-gel complex formation by contacting and drying to obtain the cell-free graft
A method for producing a cell-free graft comprising contacting a matrix with a gel to obtain a matrix-gel complex, and drying the matrix-gel complex to obtain the cell-free graft, wherein the gel is a hyaluronic acid gel and the cell-free graft comprises the matrix and the gel wherein the gel is present on at least one side of the matrix and/or penetrates the matrix at least partly.
Overall, the independent claims are directed to a cell-free graft combining a cohesive open-porosity scaffold-forming matrix with a hyaluronic acid gel that is present on at least one matrix side and can penetrate the matrix at least partly, and additionally a method that forms a matrix-gel complex by contacting followed by drying to obtain the graft.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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